ID H0WWD3_OTOGA Unreviewed; 337 AA.
AC H0WWD3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Hsp90 co-chaperone Cdc37-like 1 {ECO:0000256|ARBA:ARBA00040086};
GN Name=CDC37L1 {ECO:0000313|Ensembl:ENSOGAP00000006683.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006683.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006683.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Co-chaperone that binds to numerous proteins and promotes
CC their interaction with Hsp70 and Hsp90.
CC {ECO:0000256|ARBA:ARBA00037145}.
CC -!- SUBUNIT: Self-associates. Forms complexes with Hsp70 and Hsp90.
CC Interacts with CDC37, FKBP4, PPID and STIP1.
CC {ECO:0000256|ARBA:ARBA00038777}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR EMBL; AAQR03014697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003782952.1; XM_003782904.2.
DR AlphaFoldDB; H0WWD3; -.
DR STRING; 30611.ENSOGAP00000006683; -.
DR Ensembl; ENSOGAT00000007476.2; ENSOGAP00000006683.2; ENSOGAG00000007475.2.
DR GeneID; 100949837; -.
DR KEGG; oga:100949837; -.
DR CTD; 55664; -.
DR eggNOG; KOG2260; Eukaryota.
DR GeneTree; ENSGT00390000013443; -.
DR HOGENOM; CLU_046495_1_0_1; -.
DR InParanoid; H0WWD3; -.
DR OMA; GKWTKDD; -.
DR OrthoDB; 297041at2759; -.
DR TreeFam; TF101059; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF2; HSP90 CO-CHAPERONE CDC37-LIKE 1; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 132..289
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..120
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 337 AA; 38911 MW; 6FFC48702A2B947E CRC64;
MEQPWPPPGP WSLPRAEGET EEESDLDVSP GSPRCPQLPD GGAQMYSHGI ELACQKQKEF
VKSSVACKWN LAEAQQKLGS LALHNSESLD QEHAKAQTAI SELRQREEEW RQKEEALVQR
ERMCLWSMDA ISKDVFNKSF INQDKRKETE DEDKSKSFMQ KYEQKIRHFG MLSRWDDSQR
FLSDHPYLVC EETAKYLILW CFHLEAEQKG ALMEQIAHQA VVMQFIMEMA KNCNVDPRGC
FRLFFQKAKA EEEGYFEAFK NELEAFKSRV RLYSQSQSFQ PMTVQNHVPH SGVGSIGLLE
SLPQNPDYLQ YSINTALCSL NSVVHKEDDE PKMMDTV
//
