ID H0WXQ1_OTOGA Unreviewed; 859 AA.
AC H0WXQ1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=SH2 domain containing 3C {ECO:0000313|Ensembl:ENSOGAP00000007249.2};
GN Name=SH2D3C {ECO:0000313|Ensembl:ENSOGAP00000007249.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007249.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007249.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03035862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003785373.1; XM_003785325.1.
DR AlphaFoldDB; H0WXQ1; -.
DR STRING; 30611.ENSOGAP00000007249; -.
DR Ensembl; ENSOGAT00000008106.2; ENSOGAP00000007249.2; ENSOGAG00000008101.2.
DR GeneID; 100953954; -.
DR KEGG; oga:100953954; -.
DR CTD; 10044; -.
DR eggNOG; ENOG502QPX3; Eukaryota.
DR GeneTree; ENSGT00940000154130; -.
DR HOGENOM; CLU_015281_0_0_1; -.
DR InParanoid; H0WXQ1; -.
DR OMA; MVHNSRM; -.
DR OrthoDB; 2953960at2759; -.
DR TreeFam; TF323756; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 219..318
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 585..853
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 40..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 859 AA; 94587 MW; F3D24D4890F1433C CRC64;
MTEGPKKASK KFKFFKFKGF GSLSNLPRSF TLRRSSARIS TQSHLEPDTF DATQDDMVTV
PKSPPAYARS SDMYSHMGTM PRPSIKRAQD RRQAVQEAPE VLPEPYLVSR VLPDPPGLEA
AKEVVVGINA SLEDTPVMGL KPSVEMYPKG KSKDLMADIE ERAPEDAHPE RATGEPEAGG
DYVKFSKEKY ILDSSPEKLH KELEEELKLS STDLRSHAWY HGRIPREVSE TLVQRNGDFL
IRDSLTSLGD YVLTCRWRNQ ALHFKINKVV VKAGESYTHI QYLFEQESFD HVPALVRYHV
GSRKAVSEQS GAIIYCPVNR TFPLRYLEAS YGLSQGSSKA ASPASPSGPK GSHMKRRSVT
MTDGLTADKV TRSDGCPSST SLPHPRDSIR SCALSMDQIP DLHSPMSPIS ESPSSPAYST
VTRVHATPAA PSATALPASP VMRRSSEPQL CPGSAPKPPG DLDKGCHASP SHTLCKSSPS
PSLSSYSDPD SGHYCQLQPP IRSSREWAVT EASSRQAKSY GETLKELSEN GAPEGDWGKT
FTVPIVEATS TFNPATFQSL LIPKDNRPLE VGLLRKVKEL LTEVDARTLA RHVTKVDCLV
ARILGVTKEM QTLMGVRWGM ELLTLPHGRQ LRLDLLERFH TMSIMLAVDI LGCTGSAEER
AALLHKTIQL AAELRGTMGN MFSFAAVMGA LDMAQISRLE QTWVTLRQRH TEGAILYEKK
LKPFLKSLNE GKEGPPLSNT TFPHVLPLIT LLECDSAPAE GPEPWGSTEH GVEVVLAHLE
AARTVAHHGG LYHTNAEVKL QGFQAQPELL EVFSTEFQMR LLWGSQGASS SQARRYEKFD
KVLTALSHKL EPAVRSSEL
//
