ID   H0WZB7_OTOGA            Unreviewed;       747 AA.
AC   H0WZB7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Plakophilin 1 {ECO:0000313|Ensembl:ENSOGAP00000007926.2};
GN   Name=PKP1 {ECO:0000313|Ensembl:ENSOGAP00000007926.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007926.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000007926.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the beta-catenin family.
CC       {ECO:0000256|ARBA:ARBA00005462}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAQR03089474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03089475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03089476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WZB7; -.
DR   STRING; 30611.ENSOGAP00000007926; -.
DR   Ensembl; ENSOGAT00000008843.2; ENSOGAP00000007926.2; ENSOGAG00000008836.2.
DR   eggNOG; KOG1048; Eukaryota.
DR   GeneTree; ENSGT00940000156735; -.
DR   HOGENOM; CLU_009111_3_1_1; -.
DR   InParanoid; H0WZB7; -.
DR   OMA; NSSWGYP; -.
DR   TreeFam; TF321877; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR   GO; GO:0030057; C:desmosome; IEA:Ensembl.
DR   GO; GO:1990124; C:messenger ribonucleoprotein complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005521; F:lamin binding; IEA:Ensembl.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   GO; GO:0045110; P:intermediate filament bundle assembly; IEA:Ensembl.
DR   GO; GO:1902373; P:negative regulation of mRNA catabolic process; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR028435; Plakophilin/d_Catenin.
DR   PANTHER; PTHR10372:SF3; PLAKOPHILIN-1; 1.
DR   PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR   Pfam; PF00514; Arm; 3.
DR   SMART; SM00185; ARM; 7.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   REPEAT          287..314
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          329..372
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          595..623
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          48..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  83098 MW;  6D5304022A5626AD CRC64;
     MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQAS
     TLSHSNRGSM YDGLTDNYNY GTTSRSGYYS KFQAGTGSWG YPIYNGTLKR EPDNRRFSSY
     SQMENWSRHY PRGSCNTTGA GSDICFMQKI KASRSEPDLY CDPRGTLRKG TLASKGHKTT
     QNRYSFYSTC SGQKAVKKCP VRPPSCASKQ DPVYVPPISC NKDLSFSHSR ASSKICSEDI
     ECSGLTIPKA VQYLSSQDEK YQAIGAYYIQ HTCFQDESAK QQVYQLGGIC KLVDLLRSPN
     QNVQQAAAGA LRNLVFRSPT NKLETRRQNG IRETVNLLRR TGNTEIQKQL TGLLWNLSSS
     DELKEELIAD ALPVLVDRVI IPFSGWCDGN SNMSREVVDP EVFFNATGCL RRSLSRQELL
     VPFPHMAASG RMNLSSADAG RHTMRNYSGL IDSLMAYVQN CVAASRCDDK SVENCMCILH
     NLSYRLDAEV PTRYRQLEYN ARNTYTEKSS TGCFSNKSDK MMNNNYDCPL PEEETNPKGS
     SWLYHSDAIR TYLNLMGKSK KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPQI
     ARLLQSGNSD VVRSGASLLS NMSRHPVLHR VMGNQVFPEV TRLLTSHSGN TSNSEDILSS
     ACYTVRNLMA SQPQMAKQYF SSSMLNNVIN LCRNSASPKA AEAARLLLSD MWSIKELQSV
     LRQQGFDRNM LGTLAGANSL RNFTSRF
//