ID H0X037_OTOGA Unreviewed; 795 AA.
AC H0X037;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSOGAP00000008248.2};
GN Name=ASAP3 {ECO:0000313|Ensembl:ENSOGAP00000008248.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008248.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008248.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03020425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03020426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03020427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X037; -.
DR STRING; 30611.ENSOGAP00000008248; -.
DR Ensembl; ENSOGAT00000009208.2; ENSOGAP00000008248.2; ENSOGAG00000009200.2.
DR eggNOG; KOG0521; Eukaryota.
DR GeneTree; ENSGT00940000161085; -.
DR HOGENOM; CLU_006942_1_0_1; -.
DR InParanoid; H0X037; -.
DR OMA; IMEAQLP; -.
DR TreeFam; TF325156; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0051492; P:regulation of stress fiber assembly; IEA:Ensembl.
DR CDD; cd17900; ArfGap_ASAP3; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR047006; ASAP3_ArfGap.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 171..263
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 295..417
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 454..489
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 490..522
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 31..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 87217 MW; 61F78FAB45CA6509 CRC64;
MKGQLRDGRQ DSKKQLEKAW KDYEAKVARL EKERDRARVP GGSPGEMAQD TQRERRVFQL
HMCEYLLKAG ESQMKQGPDF LQSLIKFFHA QHNFFQDGWK AAQSLSPFIE KLAASVHALH
QAQEEELQKL TQLRDSLRGT LQLEGREEHL GRKNSGGGYS IHQHQGNKQF GTEKVGFLYK
KSDGIRRVWQ KRKCGVKYGC LTISHSTINR PPVKLTLLTC QVRPNPEEKK CFDLVTHNRT
YHFQAEDEHE CEAWVSVLQN SKDEALSSAF LGEPSGGPGS WGSTGQDSEP HDLTKLLIAE
VKSRPGNSQC CDCGAADPTW LSTNLGVLTC IQCSGVHREL GVRFSRMQSL TLDLLGPSEL
LLALNIGNTS FNEVMEAQLP SHGGPKPSAE SDMSTRRDYI VAKYVEHRFA RRSTPEPQRL
RTAICNRDLL SILEAFANGQ DFGQPLPGSD TQVPGELALH LAVKVTNQAS LPLVDFIIQN
GGHLDAKATD GNTALHYAAL CNQPDCLKLL LKGRASVGTD TVNEAGETAL DIARKKQHKE
CEELLEQAQA GTLTFPLHLD YPWGISTEPG SDSEEDEEEK VGPPASQASR WPKERARVGL
RCPLKPPAHA RWVSGRLDIS NKTYETITSL GSATPQSQSE DCPPPLPVKN TSRTTVQGCV
RHASGDRSEV PSLSSETSEA PESLGSPASS SSSLASPVEP GGPSQLPPSS EESLREPPGT
CRHSLTSGTT ASEMYLPVKF SSESTRSYRR GGRSLEDGSS ARQPLPRRNM PVGFPEGDSS
RTGVLPTSSV QLLQD
//