ID H0X201_OTOGA Unreviewed; 400 AA.
AC H0X201;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Sphingosine-1-phosphate phosphatase 2 {ECO:0000313|Ensembl:ENSOGAP00000009046.2};
GN Name=SGPP2 {ECO:0000313|Ensembl:ENSOGAP00000009046.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009046.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009046.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03030954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03030963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003784956.1; XM_003784908.1.
DR AlphaFoldDB; H0X201; -.
DR STRING; 30611.ENSOGAP00000009046; -.
DR Ensembl; ENSOGAT00000010124.2; ENSOGAP00000009046.2; ENSOGAG00000010123.2.
DR GeneID; 100963481; -.
DR KEGG; oga:100963481; -.
DR CTD; 130367; -.
DR eggNOG; KOG2822; Eukaryota.
DR GeneTree; ENSGT00940000159500; -.
DR HOGENOM; CLU_043042_1_0_1; -.
DR InParanoid; H0X201; -.
DR OMA; YWVNEQL; -.
DR OrthoDB; 2958177at2759; -.
DR TreeFam; TF323419; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042392; F:sphingosine-1-phosphate phosphatase activity; IEA:Ensembl.
DR GO; GO:0061469; P:regulation of type B pancreatic cell proliferation; IEA:Ensembl.
DR GO; GO:0006670; P:sphingosine metabolic process; IEA:Ensembl.
DR CDD; cd03388; PAP2_SPPase1; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR PANTHER; PTHR14969:SF14; SPHINGOSINE-1-PHOSPHATE PHOSPHATASE 2; 1.
DR PANTHER; PTHR14969; SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..234
FT /note="Phosphatidic acid phosphatase type 2/haloperoxidase"
FT /evidence="ECO:0000259|SMART:SM00014"
SQ SEQUENCE 400 AA; 44330 MW; EE5033DD73BF523E CRC64;
MAGLLRSLQD SQLVARFQRR CGLFPALEEG SGENGADPAE GAAQAPGVGH LSAANGKRGG
GPANGLLRSA AVPQAYVQKY IVKNYFYYYL FRFSAALGQE VFYITFLPFT HWNIDPYLSR
RLIIIWVLVM YIGQVAKDIL KWPRPSSPPV VKLEKRVIAE FGMPSTHAMA ATAIAFTFLI
CTMDRYQYPF VLGLAVAVLF STLVCLSRIY TGMHTVLDVL GGVLITGLLI VLTYPAWTLI
DCLDSASPLF PVCVIVVPFF LCYNYPVSDY YSPTRADTTT IMAAGAGVTI GCWINHFFQL
VSKPAESLPV IQNIPPLTTD MLVLGLTKFA VGIVLILLVR QLVQNLSLQV LYSWFKVVTR
NKEARRRLEI EVPYKFVTYT SVGICATTFV PMLHRFLGLL
//
