ID H0X3N3_OTOGA Unreviewed; 2541 AA.
AC H0X3N3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Zinc finger FYVE domain-containing protein 26 {ECO:0000256|ARBA:ARBA00014373};
GN Name=ZFYVE26 {ECO:0000313|Ensembl:ENSOGAP00000009750.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009750.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009750.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphatidylinositol 3-phosphate-binding protein required for
CC the abcission step in cytokinesis: recruited to the midbody during
CC cytokinesis and acts as a regulator of abcission. May also be required
CC for efficient homologous recombination DNA double-strand break repair.
CC {ECO:0000256|ARBA:ARBA00025209}.
CC -!- SUBUNIT: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with
CC TTC19 and KIF13A. {ECO:0000256|ARBA:ARBA00025962}.
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DR EMBL; AAQR03134900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03134901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03134902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03134903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03134904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03134905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000009750; -.
DR Ensembl; ENSOGAT00000010896.2; ENSOGAP00000009750.2; ENSOGAG00000010881.2.
DR eggNOG; KOG1811; Eukaryota.
DR GeneTree; ENSGT00920000149143; -.
DR HOGENOM; CLU_228199_0_0_1; -.
DR InParanoid; H0X3N3; -.
DR OMA; DWATMAV; -.
DR TreeFam; TF324517; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:1905037; P:autophagosome organization; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR CDD; cd15724; FYVE_ZFY26; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028730; ZFYVE26.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46591; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR PANTHER; PTHR46591:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1814..1874
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 595..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..777
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2541 AA; 284240 MW; 6F8DA10323980027 CRC64;
MSHPFGKEED ASQKQLFRFF CECLRRGEWE LAQACVPQLH EAQGDIPKRV EDILQALVVC
PDLLRCGQDI NPQRLAWIWL LVLEKWLAQE KKLLPAVFRR KLEFLLLAEH LPGDIPENIF
KELYETLAQG TVGPVSDGTQ RRESWTLQLS SEAVSLLWDL LRQAPQPAQA LLELLLGEDD
GTGVCHQPLQ NALVDLIRKA LPTLQGSDPG APGVVDAIYG ALRTLRCPAE PLGIEFRLLC
EELLEACRAE GSPLQEERLL SCLLHKAGRG LVSLYGHTYA EKVTEKLPRA ITSGKVSLDH
LDPGQAMLAV FSNPDPAQAW KVAYFYCLSN SKHFLEQILL TALILLKEED FPSLSRLLDR
EFRPLSRLLV LLGWTHCQSL ESAKRLLQAL HRTQDQGCGE LLKDACDGLW THLEVLEWCV
QHSSNPIPKR DLLCHLHGGD SHSVLYTLHH LTNLPALREE DVLKLLQKVP AENLQQEHVS
SDAPVPEHLS QCQTLTLYQG FCAMKYAIYA ICVNSHQHSQ CQDCKHGPSE DKASAVEPAV
DSLSSPGASN LFSTYLAKCQ QYLCSVPDSL CLELLENIFS LLFITSADLY PEPHLPEDYA
EDDDIEGKGL LGLRSPSESP QHTAQPERKS ERASLGTPGS LAYTMPSYLK AEPTDSYQGP
PGHSFLDLKH FTSGVSGFLA DEFAIGAFLK LLQERLDEIS SHDPPEKPKL PEGQSYSGSR
DGLQSRLHRF SKVLSEAQWR YKVVTSTQGS EEQPSRRYRP VTIRHSSLRR VRRTRRSRTD
GRDRGSNPSL ESTSSELSTS TSEGSLSAVS GQRELDGRLQ PQPQSSLIPM MFSPPESLLA
SCILRGNFTE AHQVVFTFNL KSSPSSGELM FMERYQEVIQ ELAQVEHKIE NQNPDGGSNS
IRRTGSGRST LQAIGSAAAA GMVFYSISDV TDKLLDSSAD PIPTLQEDFW LSTSLVEPTA
PLREVLEDLS PPAMAAFDLA CSQCQLWKTC KQLLETAERR LNSSLESRGR RLDHVLLNAD
GIRGFPVVLQ QISKILNYPL MSAGQTKSES IEEKGGGFPR CSIAELLQTC WPSLSEDCIA
SHTTLSQQLE QVLQSLRVAL ELPELRSPPL SSLVEQTAQK APGAETHPVY IQTQLLQRIL
GKQTPAGSKQ TDYMGTFFSY CSTLAAVLLQ SLSSEPDHAD IKVGNPFVLL QQSSSQLVSH
LLLERQVPPD RLAALLGREG LSLSVPQVIV NCCCEPLALC SSQQSRQTSF LLNRLGTLTQ
QHTSHWLDDL PLPTRSSLRP AENPTLERKP CSSPTDSSPP ALTSSTLAFL KSRSKLLAVV
ACLGASPRLK VTKPSLSWKE FCGRREVPLT AEQVARECER LLEQFPMLEA SLLAAWEPLQ
GSSQQGQSLA GSLCGQASLS TVLLGLHSPS ALDVLAEAFE ESLVARDWPR ALRLTEVYGR
DVDDLSSIQD AVLSCAVACD KEGWQYLFPV KDASLRSQLA LRYVDRWPLE SCLEILAYCI
SDTAVQEGLK CELQRKLAEL RVYQKVLGLQ ASPAWCDWQT LRNCCVEDPS AVMNMILEAQ
EYELCEEWGC LYPIPRERLI SLHQKHLLHL LERGDHEKAL QLLQKIPDPT MCLEVTEKSL
DQHPSLATSH FLANYLTTHF YGQLTAVRHR EIQALYVGSK VLLTLPEQHR ASYSHLSAIP
LLMLEQLLMN MKVDWATMAV QTLHQLLAGQ DIGFTMDEVD TLLSRYAGKA LDFPYPQREK
RSDSVIHLQE IVHQSSDPET LPRSPSGEFS PAALPGVSVV QSPSVRERSF PPSQPLLEFV
PPATPPARHQ WVPDETENTC MVCCREHFTM FNRRHHCRRC GRLVCSSCST KKMVVEGCRE
NPTRVCDQCY NYFNKETKER ERALRQQTDS SQHESPPYSL VVRVPKADEV EWILDLNEEE
NELVRNEFYY EQAPSASLCI AILNLHRDPT ACGHQLIEHC CRLSKGLANP EVDAGLLTDI
MKQLLFSAKM MFVKAGQSQD LALCDSYISK VDVLNILVAA AYRRVPSLDQ ILQPAAVTRL
RNQLLEAEYY QLGVEVSTKT GLDTTGAWHA WGMACLRAGN LTAAREKFSR CLKPPLDLNQ
LSHGSRLVQD VVEYLESTVR PLVSLQDDDY VATLRELEAT LRTQSLSLEV IPEGKVMNNT
YYQECLFYLH SYSTNLAIIS FYVRHSCLRE ALLHLLHKES PPEIFIEGIF QPSYKSGKLH
DLENLLESID STLESWGKYL IAACQHLQKK NYYHILYELQ QFMKDQVRAA MTCIRFFSHK
AKSYTELGEK LSWLLKAKDH LKIYLQETSR SSGRKKTTFF RKKMSAADVS RHMNTLQLQM
EVTRFLHRCE SAGTSQITTL PLPTLFGNNH MKMDVACKVM LGGKNVEDGF GIAFRVLQDF
QLDAATTYCR AARQLVEKEK YSEIRQLLKC VSESGMAAKS DGDTILLDCL EAFRRIPAQE
LEGLIQAIHN DDNKVRAYLT CCKLRSAYLI AVKQEHSRAT ALVQQVQQAA KSSGDAVVQD
ICAQWLLTNH ARSAHGSGSR K
//
