ID H0X4U9_OTOGA Unreviewed; 1461 AA.
AC H0X4U9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Alpha-2-macroglobulin like 1 {ECO:0000313|Ensembl:ENSOGAP00000010257.2};
GN Name=A2ML1 {ECO:0000313|Ensembl:ENSOGAP00000010257.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010257.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010257.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR EMBL; AAQR03127553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03127561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000010257; -.
DR Ensembl; ENSOGAT00000011460.2; ENSOGAP00000010257.2; ENSOGAG00000011443.2.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000163018; -.
DR HOGENOM; CLU_001634_0_0_1; -.
DR InParanoid; H0X4U9; -.
DR OMA; YQNAYLH; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF178; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 462..610
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 737..827
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1363..1450
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1461 AA; 161667 MW; E3A9F9462C7416B0 CRC64;
LGTLALLPAI AELLPSIAPL PRDKALRHQE NYLVTLPAQL NFPSTQKVCL DLSPGYCHVK
FTITLETKGK TQKLLEQSGL KKRNLHCISF LVPPPAGGTE EVATIQVSGI GKNVRFEEKK
KILIQRQGSG TFVQTDKPVY TPGQRVFFRI VTMNSDFVPV NDKVALPHLA DPNSNRIAQW
LEVMPRQGIV DLSFQLAPEA TLGTYTVAVA EGRTFGTFSV EEYVLPKFKV EVVEPRQLST
VQESFLIKIC CRYTYGKPVL GAVQVSACQK AYTYWNREVG QEQLPDKCRN LSGQTDKTGC
FSASVEMATF NLTGYMYYHN IDIVATVVEK GTGVEANTTQ HVYISSQMGS MTFEDTNNFY
YPNFPFRGKI KMLNHLLLPP SCSHIIIAKL PCDYRAFPNA RSSSLNVQIF EFESYKVMGW
IRTRQGKFQM EDLVYDREQV PRYYQNAYLH LQPFYNTTRS FLGIQQLSGL VKCGQPQEVL
VDYYIDPADS SHDQEVVFSY YLIGKGSLQM EGQKHLNSKK EGLKGSFSLS LTFTSRLAPN
PTLLVYAIFS SGGVIADKIQ FSVEMCFDNQ VAIGFSPAQQ LPGADVELQL QAAPGSLCAI
RAVDESVLLL RPEKALSNSS VSSLLIRREE SCPITLEENH CEDCKPSSPF PGGSTNIITT
ILTINEKSLF GACQTVGLKI LSNAKIKKPV NCSYSFPKDG RIIGGSTGAD IIPEGFSSSS
ASLPSEGSQV RQYFPETWLW DLFPIGDSGK EVVPVTVPDA ITEWKAMTFC TSQSRGFGLS
PTVGLTAFQP FFVDLTLPYS VVRGESFRLT AIVFNYLKNC IRVQTKLAES DEYQVNSWAD
SQASRCLCAD EAETYHWNIT AIKLGHVNFT ISTKILDSNE LCGGHKGFVP KEGQSDTLIK
PVLVKPEGVL VEKTHSSLLC PKGKMASESI SLEVPVDVVP DSTKAHVTVL GDIMGTALQN
LDSLVQMPSG CGEQNMVLFA PIIYVLQYLE KAGLLTEDIR SRAVGFLEIG YQKELVYKHS
NGSYSAFGEQ DGNGNTWLTA FVTKCFGQAQ KFIFIDDKIL TKAYLWLRSF QSKGMCFCNL
HIILRGAGCG GVDDEISLTA YITAALLEMG KTTDDPMVSQ GLQCLRNSVT STTNLYTQAL
LAYTLSLAGE MDTRNSLLEK LDQQAVVSGE SIHWSQKPTL TSDASPWSQP EALDVELTSY
VLLAQLIKPS LTQKDIARAT SIVAWLAKQR NAYGGFSSTQ DTVVALQALA KYATTAYVPS
EEVNLAVKSA ENFQRNFNVQ STNRLVFQQE TLPNIPGMYT LEASGQGCVY VQTVLRYNIL
PPKNTESFSL SVEMGKARCE QPTLPRSLQL TIHTSYVGSR NSSNMAIVEV KMLSGFSPLE
GTNQLLLQQP LVKKVESGTD VLNIYLDELS KETQTYTFTI SQSVLVTNLK PATIRVYDYY
LLEVFMLETF HMMWSLGQEN S
//
