ID H0X5H0_OTOGA Unreviewed; 636 AA.
AC H0X5H0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=DNM3 {ECO:0000313|Ensembl:ENSOGAP00000010524.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010524.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010524.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; AAQR03038763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X5H0; -.
DR STRING; 30611.ENSOGAP00000010524; -.
DR Ensembl; ENSOGAT00000011765.2; ENSOGAP00000010524.2; ENSOGAG00000011758.2.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000158056; -.
DR HOGENOM; CLU_008964_1_1_1; -.
DR InParanoid; H0X5H0; -.
DR OMA; EINRIFH; -.
DR TreeFam; TF300362; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF54; DYNAMIN-3; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 28..291
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 523..629
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 636 AA; 72143 MW; 4D6DA5308080CDD8 CRC64;
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG
SGIVTRRPLV LQLVTSKAEY SLLHCSFRRL NDFPAVTLEA LIKGLVGLAQ SSASVPEFNH
VSPPHMLNLT LIDLPGITKV PVGDQPPDIE YQIREMIMQF ITRENCLILA VTPANTDLAN
SDALKLAKEV DPQGLRTIGV ITKLDLMDEG TDARDVLENK LLPLRRGYVG VVNRSQKDID
GKKDIKAAML AERKFFLSHP AYRHIADRMG TPHLQKVLNQ QLTNHIRDTL PNFRNKLQGQ
LLSIEHEVEA YKNFKPEDPT RKTKALLQMV QQFAVDFEKR IEGSGDQVDT LELSGGAKIN
RIFHERFPFE IVKMEFNEKE LRREISYAIK NIHGIRQSRL FTPDMAFEAI VKKQIVKLKG
PSLKSVDLVI QELINTVKKC TKKLANFPRL CEETERIVAN HIREREGKTK DQVLLLIDIQ
VSYINTNHED FIGFANAQQR SSQVHKKTTI GNQGTNLPPS RQIVIRKGWL TISNIGIMKG
GSKGYWFVLT AESLSWYKDD EEKEKKYMLP LDNLKVRDVE KSFMSSKHIF ALFNTEQRNV
YKDYRFLELA CDSQEDVDSW KASLLRAGVY PDKSLV
//
