ID H0X8J4_OTOGA Unreviewed; 1067 AA.
AC H0X8J4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=RPS6KC1 {ECO:0000313|Ensembl:ENSOGAP00000011823.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011823.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011823.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; AAQR03176454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03176463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003802091.1; XM_003802043.2.
DR AlphaFoldDB; H0X8J4; -.
DR STRING; 30611.ENSOGAP00000011823; -.
DR Ensembl; ENSOGAT00000013198.2; ENSOGAP00000011823.2; ENSOGAG00000013193.2.
DR GeneID; 100949956; -.
DR KEGG; oga:100949956; -.
DR CTD; 26750; -.
DR eggNOG; KOG0603; Eukaryota.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00940000155656; -.
DR HOGENOM; CLU_014272_0_0_1; -.
DR InParanoid; H0X8J4; -.
DR OMA; PECQNND; -.
DR OrthoDB; 5308056at2759; -.
DR TreeFam; TF323964; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd02677; MIT_SNX15; 1.
DR CDD; cd07287; PX_RPK118_like; 1.
DR CDD; cd05576; STKc_RPK118_like; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042132; PX_S6K-delta-1.
DR InterPro; IPR035053; STK_RPK118-like.
DR PANTHER; PTHR15508; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR15508:SF2; RIBOSOMAL PROTEIN S6 KINASE DELTA-1; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00745; MIT; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..132
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 776..1057
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 309..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 118749 MW; DFF786EBBEA3374B CRC64;
MTSSRERGAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV WKRYSDFKKL
HKELWQIHKN LFRQSELFPP FAKGIVFGRF DEAVIEERRQ CAEDLLQFSA NIPALYNSKQ
LEDFFKGGII NDGSELIGPP EAYSDSLIDT FPECSTEGFS SDSDLISLTV DVDSLADLDD
GMASNQNSPS RTFGLNLSSD SSALGAVASD SEWNKTEEER ESRSLFPGSL KSKLGKRDYL
EKAGELIKLA LKKEEEDDYE AASEFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA
ESISSLYGKP QLDDLSKPPG SLSSRPPWNL RSPAEELKAF RVLGVIDKVL LVMDTRTEQT
FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV FLVLQHAEGG KLWSYISKFL
NRSPEESFEI KEMKKSAFTK VHVQQPTSSP QDSSSFESRG SDGASLLKVL PLKTSLTPSS
QDDSNQEDDG QDSSPKWPDS GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EELFLKTEGN
GVDTKAIKSF PAHLMADSGS SSTQLRAREL KFFPRDEDPE ALSSPRTSAS LSRSRNSPME
FFRIDSKDST SELLGLDFGE KLCSLKSEPL KPFFPLPDGD TISRSFNTNE SMVEFKAQDT
ISRGSDDSVP VISFKDAAFD DVSGTDEGRP DLLVNLPGEV EPAKEVAAMG PTKFTQTNMG
MIESKLLEAP DVLCLSLSTE QCQTHEQRGT EELSDPSRPK SHSIPEEHYA QEDLEALFVA
ALDGSSSGDV SLLHGSDPEF QGLGAVESAA TASSTREGLF RISSPLSGAN EYIANTDTLK
TEEILLFTDQ TEDLTKEEPT SLFQRASESK AESGLVLEGD KDIHQIFEDL DKKLALNSRF
YIPEGCIQRW AAEMVVALDA LHREGIVCRD LNPNNILLND RGHIQLTYFS RWSEVEDSCD
SDAIERMYCA PEVGAITEET EACDWWSLGA VLFELLTGKT LVECHPAGIN THTTLNMPEC
VSEEARSLIQ QLLQFNPLER LGAGVAGVED IKSHPFFTPV DWAELMR
//
