ID H0X9G3_OTOGA Unreviewed; 1038 AA.
AC H0X9G3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN Name=PITRM1 {ECO:0000313|Ensembl:ENSOGAP00000012196.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012196.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012196.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR EMBL; AAQR03044838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03044839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03044840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03044841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03044842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X9G3; -.
DR STRING; 30611.ENSOGAP00000012196; -.
DR Ensembl; ENSOGAT00000013616.2; ENSOGAP00000012196.2; ENSOGAG00000013612.2.
DR eggNOG; KOG2019; Eukaryota.
DR GeneTree; ENSGT00390000018381; -.
DR HOGENOM; CLU_009165_0_0_1; -.
DR InParanoid; H0X9G3; -.
DR OMA; NYLYYIR; -.
DR TreeFam; TF300333; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 506..754
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
SQ SEQUENCE 1038 AA; 117308 MW; 1A4A4452D34767F4 CRC64;
MWRCGGLGTL GALRSLRRRY RRTHHEVWRR SGHLACERAL QYKVGEKIHG FTINQVTSVP
ELFLTAVKLS HDDTGARYLH LAREDSNNLF SVQFRTTPMD NTGVPHILEH TVLCGSQKYP
CRDPFFKMLN RSLSTFMNAF TASDYTLYPF STQNPKDFQN LLSVYLDATF FPCLRELDFW
YEGWRLEHED PSDPQTPLIF KGVVFNEMKG AFTDNERIFS QHLQNRLLPD HTYSVVSGGD
PLCIPELTWE QLRRFHATHY HPSNARFFTY GNFPLEQHLK QIHEEALSKF RKIEPSTTVP
AQRPWDSPRE FQITCGPDAF AADPSKQTTV SVSYLLPDIT DTFEAFTLSL LSSLLISGPN
SPFYKALIES GLGTDFSPDA GYNGYTREAY FSVGLQGIAE KDIETVRVLI DRTLDEAAQK
GFEDDRIEAL LHKLEIQMKH QSTSFGLTLT SYVASCWNHD GDPVELLKLG DQLVKFRQCL
KENPDFLKEK VKQYFKNNQH KLTLSMRPDD KYHEKQVQME AEKLRQKVQS LSLEDKQQIY
RKGLELRALQ SQPQDASCLP ALKVSDIEPT MPVTELDVVL AAGDTPVQYC EQPTNGVVYF
RAFSSLNSLP RELRRYVPLF CRVLTKMGCG VLDYREQAQQ IELKTGGMTV SPHVLPDDSH
LDTYEQGVLF SSLCLDRNLP DMMHLWAEIF NSPCFEEEER FRVLVKMSAQ ELANGIPDAG
HLYASVRASQ TLTPAGDLLE TFSGMDQVRL MKNIAEMEDV TPVLRTLSLI GTHLLTCDDM
RCSMNMTPQQ RPRAEQEVER FLGTLGRGGR EPKPVHPHVV EKPAHSGPGG NADACGSQIV
RKLITEPTFQ PCQMKTHFPL PFQVNYVGEC IRTVPYTDPG HASLKILARL MTAKFLHMEI
REKGGAYGGG AKLSHSGVFT FYSYRDPNSM ETLQAFGKAV DWAKSGAFTQ QDVEEAKLSV
FSAVDAPVAP SDKGLDHFLY GLSDEMKQAH REQLFMVSHD SLVAASHTYL GTGRSPHGVA
ILGPENAEIA QDPSWTIR
//
