ID H0XBX3_OTOGA Unreviewed; 889 AA.
AC H0XBX3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=SH3 domain binding protein 4 {ECO:0000313|Ensembl:ENSOGAP00000013240.2};
GN Name=SH3BP4 {ECO:0000313|Ensembl:ENSOGAP00000013240.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013240.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013240.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR EMBL; AAQR03182592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XBX3; -.
DR STRING; 30611.ENSOGAP00000013240; -.
DR Ensembl; ENSOGAT00000014782.2; ENSOGAP00000013240.2; ENSOGAG00000014779.2.
DR eggNOG; ENOG502QTUW; Eukaryota.
DR GeneTree; ENSGT00390000013151; -.
DR HOGENOM; CLU_013080_2_0_1; -.
DR InParanoid; H0XBX3; -.
DR OMA; RQNKSHY; -.
DR TreeFam; TF105572; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0061462; P:protein localization to lysosome; IEA:Ensembl.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR15603:SF3; SH3 DOMAIN-BINDING PROTEIN 4; 1.
DR PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 55..114
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 317..454
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 654..724
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 869..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 98535 MW; E7A1E328286C870D CRC64;
MAAQRIRAAN SNGLPRCKSE GTLIDLSGGF SETSFNDVKV PSPSALLGDS PIPFGNAKEV
IAIKDYCPTN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE MGYIPSSHVQ PLNYRNSTLS
DSGVIDNLPD SPDEVATELE LLGEWPDDKQ VLGRTHSNNP FWNGVQTNPF LNGSVPVTPS
LGELNPKSTV DLLLFDTGTS SFTESSSATT NSTGNIFDEL PVPNGLLAEQ PAKRDNPFFR
SKRSYSLSEL SVLQAKADTP ISSSFFTGLK SPAPEQFQSR EDFRTAWLTH RKLARSCHDL
DLLGQSPGWG QTQAVETNIV CKLDSSGGAV QLPDTSISIH VPEGHVPPGE TQQISMKALL
DPPLELSSDK SSSISPVLEV KLSNLEVKTF LILEMKVSAE VKNDLFSRST VGIQCLRSDS
KEGPYVSIPL AYSCGDTIQV QLDNLEPCMY LAVVAHGPNI LYPSTVWDFI HKKVTVGLYG
PKHIHPSFKT VVTIFGHDCA PKTLLVSEVT RQAPSPAPVA LQLWGKHQFI LSRPQDLKVC
MFSNMTNYEV KAGEQAKVVR GFQMKLGKVS RLIFPITSHS PSELSDFTLR VQVKDDQEAI
LTQFCVQTPQ PPPKSAIKPS GQRRFLKKNE VGKIILSPFA ATTRYPTFQD RPVSSLKFGK
LLKTVVRQNK NHYLLEYKKG DGIALLSEER IRLKGQLWTK EWYIGYYQGR VGLVHAKNVL
VVGKARPSLL SGPELSTAVL LEQILRPCKF LTYIYASVRT LLMENISSWR AFADALGYAH
LPLTFFCRAE LDSEPERVAS VLEKLKEDCN DAGNKERKSF QKELVMALLK MDCQGLVVRL
IQDFVLLTTA VEVAQRWREL AEKLAKVSKQ QMDAYESPHR DRNGVVDSE
//
