ID H0XCZ8_OTOGA Unreviewed; 73 AA.
AC H0XCZ8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Small nuclear ribonucleoprotein G {ECO:0000256|RuleBase:RU365052};
DE Short=snRNP-G {ECO:0000256|RuleBase:RU365052};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013702.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013702.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays role in pre-mRNA splicing as core component of the SMN-
CC Sm complex that mediates spliceosomal snRNP assembly and as component
CC of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome. Component of both the
CC pre-catalytic spliceosome B complex and activated spliceosome C
CC complexes. Is also a component of the minor U12 spliceosome. As part of
CC the U7 snRNP it is involved in histone 3'-end processing.
CC {ECO:0000256|RuleBase:RU365052}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|RuleBase:RU365052}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365052}.
CC Note=SMN-mediated assembly into core snRNPs occurs in the cytosol
CC before SMN-mediated transport to the nucleus to be included in
CC spliceosomes. {ECO:0000256|RuleBase:RU365052}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC {ECO:0000256|ARBA:ARBA00006850, ECO:0000256|RuleBase:RU365052}.
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DR EMBL; AAQR03102145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XCZ8; -.
DR STRING; 30611.ENSOGAP00000013702; -.
DR Ensembl; ENSOGAT00000015303.2; ENSOGAP00000013702.2; ENSOGAG00000015300.2.
DR eggNOG; KOG1780; Eukaryota.
DR GeneTree; ENSGT00510000046985; -.
DR HOGENOM; CLU_076902_10_1_1; -.
DR InParanoid; H0XCZ8; -.
DR OMA; THIDIGM; -.
DR TreeFam; TF315099; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0034709; C:methylosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0034719; C:SMN-Sm protein complex; IEA:Ensembl.
DR GO; GO:0005685; C:U1 snRNP; IEA:Ensembl.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IEA:Ensembl.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:Ensembl.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; IEA:Ensembl.
DR GO; GO:0005687; C:U4 snRNP; IEA:Ensembl.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:Ensembl.
DR GO; GO:0005683; C:U7 snRNP; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR CDD; cd01719; Sm_G; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR InterPro; IPR044641; Lsm7/SmG-like.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR001163; Sm_dom_euk/arc.
DR InterPro; IPR034098; Sm_G.
DR PANTHER; PTHR10553; SMALL NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR10553:SF26; SMALL NUCLEAR RIBONUCLEOPROTEIN G-RELATED; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS52002; SM; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU365052};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU365052};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|RuleBase:RU365052};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365052};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Ribonucleoprotein {ECO:0000256|RuleBase:RU365052};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU365052};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|RuleBase:RU365052}.
FT DOMAIN 3..73
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
SQ SEQUENCE 73 AA; 8076 MW; 7526D4CCE2DEC873 CRC64;
MSKAHPPELK NVDQAWNVKL NGGRHVQGIL RGFDPFMNLV IDECVEMATS GQQNNIGMVV
IRGNSIIMLE ALE
//
