ID H0XD63_OTOGA Unreviewed; 454 AA.
AC H0XD63;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Meis homeobox 1 {ECO:0000313|Ensembl:ENSOGAP00000013789.2};
GN Name=MEIS1 {ECO:0000313|Ensembl:ENSOGAP00000013789.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013789.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013789.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family.
CC {ECO:0000256|ARBA:ARBA00009661}.
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DR EMBL; AAQR03102428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XD63; -.
DR STRING; 30611.ENSOGAP00000013789; -.
DR Ensembl; ENSOGAT00000015403.2; ENSOGAP00000013789.2; ENSOGAG00000015399.2.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000156327; -.
DR HOGENOM; CLU_023139_1_1_1; -.
DR InParanoid; H0XD63; -.
DR OMA; MSMGQPS; -.
DR TreeFam; TF318093; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF126; HOMEOBOX PROTEIN MEIS1; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 259..322
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 261..323
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 29..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 49592 MW; 0FEE9FE7DF3EDAC4 CRC64;
MDGVGIPSTM YADPHAARSM QPVHHLNHGP PLHSHQYPHT AHTNAMAPSM GSSVNDALKR
DKDAIYGHPL FPLLALIFEK CELATCTPRE PGVAGGDVCS SESFNEDIAV FAKQIRAEKP
LFSSNPELDN LMIQAIQVLR FHLLELEKVH ELCDNFCHRY ISCLKGKMPI DLVIDDREGG
SKSDSEDITR SANLTDQHQP SWNRDHDDTA STRSGGTPGP SSGGHTSHSG DNSSEQGDGL
DNSVASPSTG DDDDPDKDKK RHKKRGIFPK VATNIMRAWL FQHLTHPYPS EEQKKQLAQD
TGLTILQVNN WFINARRRIV QPMIDQSNRA VSQGTPYNPD GQPMGGFVMD GQQHMGIRAP
GLQSMPGEYI ARGGPMGVSM GQPSYTQPQM PPHPAQLRHG PPMHTYIPGH PHHPTVMMHG
GPPHPGMPMS ASSPTVLNTG DPTMSGQVMD IHAQ
//
