ID   H0XDY9_OTOGA            Unreviewed;       531 AA.
AC   H0XDY9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Ceramide kinase {ECO:0000313|Ensembl:ENSOGAP00000014120.2};
GN   Name=CERK {ECO:0000313|Ensembl:ENSOGAP00000014120.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014120.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000014120.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AAQR03015709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03015710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03015711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03015712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0XDY9; -.
DR   STRING; 30611.ENSOGAP00000014120; -.
DR   Ensembl; ENSOGAT00000015769.2; ENSOGAP00000014120.2; ENSOGAG00000015762.2.
DR   eggNOG; KOG1115; Eukaryota.
DR   GeneTree; ENSGT00940000156976; -.
DR   HOGENOM; CLU_013399_2_2_1; -.
DR   InParanoid; H0XDY9; -.
DR   OMA; GSQTYER; -.
DR   TreeFam; TF314514; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0001729; F:ceramide kinase activity; IEA:Ensembl.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR   GO; GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
DR   Gene3D; 2.60.200.40; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR045363; CERK_C.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF25; CERAMIDE KINASE; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF19280; CERK_C; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          128..278
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
SQ   SEQUENCE   531 AA;  59280 MW;  B71DC9155261BF24 CRC64;
     MGARRAAEPL HSVLWVKQQR CVVSLEPARA LLRWWRSPGP GAGAPGADAC SVPVAEIITV
     EEVDVCGKHG SGGRWQKMEK PYGFTVHCVK RAQRHRWKWA QVTFWCLEEQ LCHLWLQTLR
     AMLETLTSRP KHLLVFINPF GGKGKGKRIY EQKVAPLFTL ASITTEIIVT EHANQATETL
     YEINLDKYDG IVCVGGDGMF SEVLHGLVGR TQRSAGVDQN HPRATLVPSS LRIGIIPAGS
     TDCVCYSTVG TNDAQTSALH IVVGDSLPLD VSSVHHHGSL LRYSVSLLGY GFYGDIVRDS
     EKKRWMGLIR YEFSGLKTFL SHHSYDGTVS FLPAQHTVGS PRDGKPCRAG CFICRQSKQQ
     LEEEQKKALY GLESAEEVEE WQVVSGKFLA INATNMVCAC HRCPGGLSPA AHLGDGSCDL
     ILIRKCSRFN FLRFLFRHTN QYDQFDFSFV EVYRVKKFQF SSKHMEDEDS DLKERGKKRL
     GQLCGEHCSC CCPVSSSSWN CDGEVLQNTA IEVRVHCQLV RLFARGIEDN A
//