ID H0XEB7_OTOGA Unreviewed; 1740 AA.
AC H0XEB7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=DS cell adhesion molecule {ECO:0000313|Ensembl:ENSOGAP00000014283.2};
GN Name=DSCAM {ECO:0000313|Ensembl:ENSOGAP00000014283.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014283.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014283.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; AAQR03141143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000014283; -.
DR Ensembl; ENSOGAT00000015953.2; ENSOGAP00000014283.2; ENSOGAG00000015945.2.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000154678; -.
DR HOGENOM; CLU_001038_0_1_1; -.
DR InParanoid; H0XEB7; -.
DR OMA; DGFDHHK; -.
DR TreeFam; TF316846; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:1990890; F:netrin receptor binding; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0048842; P:positive regulation of axon extension involved in axon guidance; IEA:Ensembl.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05734; Ig_DSCAM; 1.
DR CDD; cd05735; Ig_DSCAM; 1.
DR CDD; cd20958; IgI_5_Dscam; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF51; DOWN SYNDROME CELL ADHESION MOLECULE; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 5.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 8.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 8.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1438..1459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..141
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 151..241
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 247..340
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 344..432
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 436..525
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 530..623
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 627..723
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 728..825
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 830..929
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 934..1030
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1034..1128
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1128..1220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1222..1316
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1317..1418
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1561..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1698..1740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1625..1652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1698..1712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1740 AA; 192155 MW; EA35A1B2FA02D41C CRC64;
LSSVLGSRFL ITSTGALYIK DVQNEDGLYN YRCITRHRYT GETRQSNSAR LFVSDPANSA
PSILDGFDHR KAMAGQRVEL PCKALGHPEP DYRWLKDNMP LEISGRFQKT VTGLLIENTR
PSDSGSYVCE VSNRYGTAKV IGRLYVKPKS PEPLKATISP RKVKSSVGSQ VSLSCSVTGS
EDQELSWYRN GEILNPGKNV RITGINHENL IMDHMVKSDG GAYQCFVRKD KLSAQDYVQV
VLEDGTPKII SAFSEKVVSP SEPVSLMCNV KGTPLPTITW TLDDDPILKG GSHRISQMIT
SEGNVVSYLN ISSSQVRDGG VYRCTANNSA GVVLYQARIN VRGPASIRPM KNITAIAGRD
TYIHCRVIGY PYYSIKWYKN SNLLPFNHRQ VAFENNGTLK LSDVQKEVDE GEYTCNVLVQ
PQLSTSQSVH VTVKVPPFIQ PFEFPRFSIG QRVFIPCVVV SGDLPITITW QKDGRPIPGS
LGVTIDNIDF TSSLRISNLS LVHNGNYTCI ARNEAAAVEH QSQLIVRVPP KFVVQPRDQD
GIYGKAVILN CSAEGYPVPT IVWKFSKGAG VPQFQPIALN GRIQVLSNGS LLIKHVVEED
SGYYLCKVSN DVGADVSKSM YLTVKIPAMI TSYPNTTLAT QGQKKEMSCT AHGEKPIIVR
WEKEDRIINP EMARYMVSTK EVGEEVISTL QILPTVREDS GFFSCHAINS YGEDRGIIQL
TVQDGTEPPD PPEIEIKDVK ARTITLRWTM GFDGNSPITG YDIECKNKSD SWDSAQRTKD
VSPQLNSATI IDIHPSSTYS IRMYAKNRIG KSQPSNELTV TADEAAPDGP PQEVHLEPIS
SQSIRVTWKA PKKHLQNGII RGYQIGYREY STGGNFQFNI VSIDTTGDSE VYTLDNLSKF
TQYGLVVQAC NRAGTGPSSQ EIITTTLEDV PSYPPENVQA IATSPESISI SWSTLSKEAL
NGILQGFRVI YWANLMDGEL GEIKNVTTTQ PSLELDGLEK YTNYSIQVLA FTRAGDGVRS
EQIFTRTKED VPGPPAGVKA AAASASMVFV SWLPPLKLNG VIRKYTVFCS HPYPTVISEF
EASPDSFSYR IPNLSRNRQY SVWVVAVTSA GRGNSSEIIT VEPLAKAPAR ILTFSGTVTT
PWMKDIVLPC KAVGDPSPAV KWMKDSNGTP SLVTIDGRRS VFSNGSFIIR TVKAEDSGYY
SCIANNNWGS DEIILNLQVQ VPPDQPRLTV SKTTSSSITL SWLPGDNGGS SIRGYILQYS
EDNSEQWGSF PISPSERSYR LENLKCGTWY KFTLTAQNGV GPGRISEIIE AKTLGKEPQF
SKEQELFASI NTTRVRLNLI GWNDGGCPIT SFTLEYRPFG TTVWTTAQRT SLSKSYILYD
LQEATWYELQ MRVCNSAGCA EKQANFATLN YDGSTIPPLI KSVVQSEEGL TTNEGLKMLV
TISCILVGVL LLSVLLLVLR RRRREQRLKR LRDAKSLAEM LMSKNTRTSD TLSKQQQTLR
MHIDIPRAQL LIEERDTMET IDDRSTVLLT DADFGEAAKQ KSLTVTHTVH YQSVSQATGP
LVDVSDARPG TNPTTRRNAK AGPTTRNRYA SQWTLNRPHP TISAHTLTTD WRLPTPRAAG
SVDKESDSYS VSPSQDTDRA RSSMVSTESA SSTYEELARA YEHAKMEEQL RHAKFTITEC
FISDTSSEQL TAGTNEYTDS LTSSTPSESG ICRFTASPPK PQDGGRVMNM AVPKAHRPGE
//
