ID H0XFG4_OTOGA Unreviewed; 298 AA.
AC H0XFG4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Ribonuclease H2 subunit B {ECO:0000256|ARBA:ARBA00019062};
DE AltName: Full=Ribonuclease HI subunit B {ECO:0000256|ARBA:ARBA00033464};
GN Name=RNASEH2B {ECO:0000313|Ensembl:ENSOGAP00000014754.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014754.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014754.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC replication, possibly by mediating the removal of lagging-strand
CC Okazaki fragment RNA primers during DNA replication. Mediates the
CC excision of single ribonucleotides from DNA:RNA duplexes.
CC {ECO:0000256|ARBA:ARBA00024778}.
CC -!- SUBUNIT: The RNase H2 complex is a heterotrimer composed of the
CC catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and
CC RNASEH2C. {ECO:0000256|ARBA:ARBA00011277}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNase H2 subunit B family.
CC {ECO:0000256|ARBA:ARBA00009823}.
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DR EMBL; AAQR03165155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03165156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XFG4; -.
DR STRING; 30611.ENSOGAP00000014754; -.
DR Ensembl; ENSOGAT00000016490.2; ENSOGAP00000014754.2; ENSOGAG00000016486.2.
DR eggNOG; KOG4705; Eukaryota.
DR GeneTree; ENSGT00390000011439; -.
DR HOGENOM; CLU_059802_0_0_1; -.
DR InParanoid; H0XFG4; -.
DR OMA; AQWVLIA; -.
DR TreeFam; TF105250; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032299; C:ribonuclease H2 complex; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0009259; P:ribonucleotide metabolic process; IEA:Ensembl.
DR GO; GO:0006401; P:RNA catabolic process; IEA:Ensembl.
DR CDD; cd09270; RNase_H2-B; 1.
DR Gene3D; 1.10.20.120; -; 1.
DR Gene3D; 2.20.25.530; -; 1.
DR InterPro; IPR040456; RNase_H2_suB.
DR InterPro; IPR019024; RNase_H2_suB_wHTH.
DR InterPro; IPR041195; Rnh202_N.
DR PANTHER; PTHR13383; RIBONUCLEASE H2 SUBUNIT B; 1.
DR PANTHER; PTHR13383:SF11; RIBONUCLEASE H2 SUBUNIT B; 1.
DR Pfam; PF09468; RNase_H2-Ydr279; 1.
DR Pfam; PF17745; Ydr279_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 16..78
FT /note="Rnh202 triple barrel"
FT /evidence="ECO:0000259|Pfam:PF17745"
FT DOMAIN 81..214
FT /note="Ribonuclease H2 subunit B wHTH"
FT /evidence="ECO:0000259|Pfam:PF09468"
SQ SEQUENCE 298 AA; 34127 MW; 8094AC8B8C7371AD CRC64;
KNLYLFPEYL KDASKKMKHG LMFVKLVNPC SGEGAIYLFD MYLQQLFEVK VFKEKYHSWF
INQSVQSGGA LHFATPVDPL FLLLHYLMKA GKEGKFQPLD QVVVDDIFPN SILLLKLPEL
EKSLCHVTEE KVNPEITNKK YYKYSKEKTL KWLEKKVNQT MAALKTNNVN VSARVLSTAF
FSSDQVASDK EEDYIRYAHG LISEYIPKEL SDDLSKHLQL PELPASWPNP PSKKIKLSDE
PVEAKEDYTK FNTKDLKTEK KNNKMTAAQK ALAKVDKSGM KSIDTFFGAK IKKKTGKI
//
