ID H0XKG1_OTOGA Unreviewed; 1533 AA.
AC H0XKG1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSOGAP00000016601.1};
GN Name=ARAP3 {ECO:0000313|Ensembl:ENSOGAP00000016601.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016601.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016601.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03009001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000016601; -.
DR Ensembl; ENSOGAT00000029476.1; ENSOGAP00000016601.1; ENSOGAG00000030775.1.
DR eggNOG; KOG1117; Eukaryota.
DR GeneTree; ENSGT00940000158869; -.
DR HOGENOM; CLU_002900_1_0_1; -.
DR InParanoid; H0XKG1; -.
DR OMA; CETVFQS; -.
DR TreeFam; TF105769; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17902; ArfGap_ARAP3; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 8..63
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 275..367
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 382..471
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 468..599
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 895..1076
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1105..1198
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1211..1313
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 72..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1402..1533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1533 AA; 168742 MW; 0BCAFD062F152DA3 CRC64;
MAAPQDLDIA VWLATVHLEQ YADTFRRHGL ATAGAARALG HEELRQLGIS ATGHRKRILR
LLQIGTVEGS LDLKSNSTME PSPSPAPPAH LSKPVPKPRT VFGLNSPATT QRPGLSLESR
PRSPPFPTSS SKQTSTLNTM EMMPNAIYFG LDLRGGAQAA QDMAPDSSQT AAPIPALRPT
TGTVHIMDPG CLYYGVQPVG IPGTPDRREG RGVGQDRIEH SLSRQDPEAR EDVGYASLEL
PGDSTLSLPT LDTEETGDDL ISPYASFSST ADRPTPLLSG WLDKLSPQGN YVFQRRFVQF
NGRSLMYFGS DKDPFPKGVI PLTAIEMTRG SKDNKFQVIT SQRVFMFRTE SEAQRDMWCS
TLQSCLKEQR LLGHPRPPQP PRPLRTGVLE LRGHKAKVFA ALSPGELALY KSEQAFTLGI
GICFIELQGC SVRETKSRSF DLLTPHRCFS FTAESGGARQ SWAAALQEAV TETLSDYEVA
EKIWSNRANR HCADCGASRP DWAAVNLGVV ICKQCAGQHR ALGSGISKVQ SLKLDTSVWS
NEIVQLFIVL GNDRANRFWA GTLPPGEGLY PDSNPGPRGE FISRKYKLGL FRKPHPQYPD
HSQLLQALCA AVAGPNLLKN MAQLLCVEAS EDEEPWSPAA PDGSFPGHLP ADPSPGVYNE
VVVPATYSGF LYCGPISNKA GPPPPRRGRD VPPRLWCVLG AALEMFASES SPEPVSLIQP
QDVVCLGVSP PPTDPGDLFP FSFELILTGG KIQHFSTDGA DSLEAWTSAM GKWFSPLSCH
QLLGPGLLRL GRLWLRSPSH TALAPGLWLS AFGLLRGDHL FLCPAPGPGP PAPEDMVHLR
RLQEISVVPA ADTPDKKEHL VLVETGRTLY LQGEGRLDFS AWNTAIGGAA GGGGTGLQEQ
QMSRGDIPII VDACISFVTQ HGLRLEGVYR KGGARARSLK LLAEFRRDAR SVKLRPGEHF
VEDVTDTLKR FFRELDDPVT SARLLPRWRE AAELPQKDQR LEKYKEVIGS LPRVNRRTLA
TLIGHLYRVQ KCAALNQMCT RNLALLFAPS VFQTDGRGEH EVRVLQELID GYVSVFDIDS
DQVAQIDLEV NLITTWKDVQ LSQAGDLIME VYIEQQLPDN CVTLKVSPTL TAEELTNQVL
EIRGTAAGTD LWVTFEIREH GELERPLHPK EKVLEQALQW CQLPEPCSAS LLLKKVSLAQ
ASCLFTGIRR ESPRVGLLRC REEPPRLLGS RFQERFFLLR GRCLLLLKEK KSSKPEREWP
LEGAKVYLGI RKKLKPPTLW GFTLILEKMQ LYLSCTDEDE MWDWTTSILK AQHDDQQPLV
LRRRSSSDLA RQKFGTMPLL PIHGDDSGAT LLSANQTLRR LHNRRTLSMF FPMKSSQGSV
EEQEELEEPV YEEPVYEEVG AFPELTQDTS TSSAIQERTD KTEIPLTSQK SFDQPLLSKA
STLNQEERPP EPPPGPPSKS NPQAQGSLEE QLLQELSSLI LRKGETIGGP GSPSQPSSPQ
TPSSSSTGLP TRTPSFPTQS SCTSSPPSSQ PLT
//
