ID H0XL41_OTOGA Unreviewed; 653 AA.
AC H0XL41;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=TNF receptor superfamily member 21 {ECO:0000313|Ensembl:ENSOGAP00000016831.1};
GN Name=TNFRSF21 {ECO:0000313|Ensembl:ENSOGAP00000016831.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016831.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016831.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; AAQR03061444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XL41; -.
DR STRING; 30611.ENSOGAP00000016831; -.
DR Ensembl; ENSOGAT00000027208.1; ENSOGAP00000016831.1; ENSOGAG00000000190.2.
DR eggNOG; ENOG502QVMX; Eukaryota.
DR GeneTree; ENSGT00940000156212; -.
DR InParanoid; H0XL41; -.
DR OMA; QVGTQWI; -.
DR TreeFam; TF331157; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:Ensembl.
DR GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032696; P:negative regulation of interleukin-13 production; IEA:Ensembl.
DR GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl.
DR GO; GO:0031642; P:negative regulation of myelination; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0097252; P:oligodendrocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0048713; P:regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR CDD; cd01671; CARD; 1.
DR CDD; cd08778; Death_TNFRSF21; 1.
DR CDD; cd10583; TNFRSF21; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022330; TNFR_21.
DR InterPro; IPR034037; TNFRSF21_death.
DR InterPro; IPR034034; TNFRSF21_N.
DR PANTHER; PTHR46921; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR PANTHER; PTHR46921:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01971; TNFACTORR21.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..128
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 87..128
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 412..495
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 213..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 88..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 110..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 653 AA; 71599 MW; 3F1A4A9AB0BB04B9 CRC64;
IYVPSWSSGA LPWCQEMAAL HLGLGKEQLL GFLSTTTAQP EQKASNLVGT YRHVDRATGQ
VLICDKCPAG TYVSEHCTNT SLRVCSSCPA GTFTRHENGI ERCHDCSQPC PWPMVEKLPC
AALTDRECTC PPGMFQSNAT CAPHTVCPVG WGVRKKGTET EDVRCKQCAR GTFSDVPSSV
MKCKAYTDCL SQNLVVIKPG TKEADNVCGT LPSLSSTTSP PPGTAIFSHP EHTDSHEVPS
STYVPKGMNS TESNSSASVR PKVLSGTQEG TVPDNTSSAS GEEGMNKTLP NLQVVNHQQG
PHHRHILKLL PAMEATGGEK SSTPMKGPKR AHPRQNMHKH FDINEHLPWM IVLFLLLVLV
VIVVCSIRKS SRTLKKGPRQ DPSAIVEKAG LKKSVTPTQN REKWIYYCNG HGIDILKLVA
AQVGSQWKDI YQFLCNASER EVAAFSSGYT ADHERAYAAL QHWTIRGPEA SLAQLISALR
QHRRNDVVEK IRGLMEDTTQ LDATLISLVV MPAPFLGPSP VPSPNTKLEN STLLTVEPSP
LDKNKGFFVD ESEPLLRCDS TSSGSSALSR NGSFITKEKK DTVLRQVRLD PCDLQPIFDD
MLHILNPEEL RVIEEIPQAE DKLDRLFEII GVKSQEASQT LLDSVYSHLP DLL
//
