ID H0XL49_OTOGA Unreviewed; 292 AA.
AC H0XL49;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=F-box/SPRY domain-containing protein 1 {ECO:0000256|ARBA:ARBA00016614};
DE AltName: Full=F-box only protein 45 {ECO:0000256|ARBA:ARBA00029979};
GN Name=FBXO45 {ECO:0000313|Ensembl:ENSOGAP00000016839.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016839.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the FBXO45/Fsn family.
CC {ECO:0000256|ARBA:ARBA00007328}.
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DR EMBL; AAQR03094194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03094195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XL49; -.
DR STRING; 30611.ENSOGAP00000016839; -.
DR Ensembl; ENSOGAT00000027982.1; ENSOGAP00000016839.1; ENSOGAG00000033173.1.
DR eggNOG; KOG3953; Eukaryota.
DR GeneTree; ENSGT01030000234629; -.
DR HOGENOM; CLU_046756_1_0_1; -.
DR InParanoid; H0XL49; -.
DR OMA; NNEVWRY; -.
DR TreeFam; TF312822; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0099524; C:postsynaptic cytosol; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0099523; C:presynaptic cytosol; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0021960; P:anterior commissure morphogenesis; IEA:Ensembl.
DR GO; GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Ensembl.
DR GO; GO:0021800; P:cerebral cortex tangential migration; IEA:Ensembl.
DR GO; GO:0021957; P:corticospinal tract morphogenesis; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
DR GO; GO:0060386; P:synapse assembly involved in innervation; IEA:Ensembl.
DR CDD; cd22111; F-box_FBXO45; 1.
DR CDD; cd12907; SPRY_Fbox; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035784; SPRY_FBXO45.
DR PANTHER; PTHR12245:SF7; F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 39..88
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 98..290
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 292 AA; 31360 MW; DC0E5AA2E439F1B0 CRC64;
LGPAGEVMAA PTPGAGGASG GAGCSSSGGA GAGSGSGSAG AGGRLPSRVL ELVFSYLELS
ELRNCALVCK HWYRCLHGDE NSEVWRSLCA RRLAEEALRT DILCNLPSYK AKVRAFQHAF
STNDCSRNVY IKKNGFTLHR NPIAQSTDGA RTKIGFSEGR HAWEVWWEGP LGTVAVIGIA
TKRAPMQCQG YVALLGSDDQ SWGWNLVDNN LLHNGEVNGS FPQCNNAPKY QIGERIRVIL
DMEDKTLAFE RGYEFLGVAF RGLPKVCLYP AVSAVYGNTE VTLVYLGKPL DG
//
