ID H0XLF0_OTOGA Unreviewed; 281 AA.
AC H0XLF0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=E3 ubiquitin-protein ligase ZNRF1 {ECO:0000256|ARBA:ARBA00040227};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=RING-type E3 ubiquitin transferase ZNRF1 {ECO:0000256|ARBA:ARBA00042177};
DE AltName: Full=Zinc/RING finger protein 1 {ECO:0000256|ARBA:ARBA00042305};
GN Name=ZNRF1 {ECO:0000313|Ensembl:ENSOGAP00000016940.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016940.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016940.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000256|ARBA:ARBA00004177}.
CC Lysosome {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; AAQR03081537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XLF0; -.
DR STRING; 30611.ENSOGAP00000016940; -.
DR Ensembl; ENSOGAT00000032872.1; ENSOGAP00000016940.1; ENSOGAG00000032150.1.
DR eggNOG; KOG0801; Eukaryota.
DR GeneTree; ENSGT00940000159278; -.
DR HOGENOM; CLU_062700_0_0_1; -.
DR InParanoid; H0XLF0; -.
DR OMA; MGIDHNA; -.
DR TreeFam; TF317681; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR CDD; cd16694; mRING-CH-C4HC2H_ZNRF1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46661:SF2; E3 UBIQUITIN-PROTEIN LIGASE ZNRF1; 1.
DR PANTHER; PTHR46661; E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 238..278
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 30056 MW; 3F4D8FD350F2391B CRC64;
MGGKQSTAAR SRGPFPGVST DDSAVPPPGG APHFGHYRTG GGAMGLRSRS VSSVAGMGMD
PSTAGGVPFG LYTPSSRGTG DSERAPGGGG SASDSTYAHG NGYQETGGGH HRDGMLYLGS
RASLADALPL HIAPRWFSSH SGFKCPICSK SVASDEMEMH FIMCLSKPRL SYNVRTQRSL
RGAWPGRTWL LESSGRTLQG QLWRTECSWG QRVRVTSYTH SPLSPFTDDV LTKDAGECVI
CLEELLQGDT IARLPCLCIY HKSCIDSWFE VNRSCPEHPA D
//
