ID H0XVM1_OTOGA Unreviewed; 734 AA.
AC H0XVM1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Phospholipid phosphatase related 3 {ECO:0000313|Ensembl:ENSOGAP00000020163.1};
GN Name=PLPPR3 {ECO:0000313|Ensembl:ENSOGAP00000020163.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000020163.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000020163.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000256|ARBA:ARBA00008816}.
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DR EMBL; AAQR03058596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03058597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03058598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03058599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XVM1; -.
DR STRING; 30611.ENSOGAP00000020163; -.
DR Ensembl; ENSOGAT00000031576.1; ENSOGAP00000020163.1; ENSOGAG00000027257.1.
DR eggNOG; KOG3030; Eukaryota.
DR GeneTree; ENSGT00940000160280; -.
DR HOGENOM; CLU_021458_8_0_1; -.
DR InParanoid; H0XVM1; -.
DR OMA; GNPWEWA; -.
DR TreeFam; TF316040; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR CDD; cd03384; PAP2_wunen; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR PANTHER; PTHR10165; LIPID PHOSPHATE PHOSPHATASE; 1.
DR PANTHER; PTHR10165:SF14; PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 3; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 138..282
FT /note="Phosphatidic acid phosphatase type 2/haloperoxidase"
FT /evidence="ECO:0000259|SMART:SM00014"
FT REGION 317..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..466
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 77683 MW; C5127FD6DB108156 CRC64;
ARGTMISTKE KNKTPKDSMT LLPCFYFVEL PIVASSIVSL YFLELTDLFK PAKVGFQCYD
RTLSMPYVET NEELIPLLML LSLAFAAPAA SIMVGEGMLY CLQSRLWGRG GGPGGAEGSI
NAGGCNFNSF LRRTVRFVGV HVFGLCATAL VTDVIQLATG YHAPFFLTVC KPNYTLLGTS
CEVNPYITQD ICSGHDTHAI LSARKTFPSQ HATLSAFAAV YVSMYFNSVI SDTTKLLKPI
LVFAFAIAAG VCGLTQITQY RSHPVDVYAG FLIGAGIAAY LACHAVGNFQ APLADKPVAP
APSKDALRAL TQRGHDSVYQ QNKSVSTDEL GPPGRLEGVS RPVAREKTSL GSLKRASVDV
DLLAPRSPMG KENMVTFSNT LPRVNTPSLD DPARRHMTIH VPLDASRSKQ LISEWKQKSL
EGRGLGLSDE ASPGHLRAPT EPMAEEEEEE EEEEEEEEED EEEDGPAPPS LYPTVQARPG
LGPRVILPSR AGPQPLVHIP EEGVQAGASL SPKSSATVRA KWLMMAEKGG AAMASSTTQP
RVANPPRLLQ VIAMSKAPGG AGPKAAETAS SSSASSDSSQ YRSPSDRDSA SIVTIDAHAP
HHPVVHLSAG NAPWEWKAAG GGAKVVEGEG GYELGDLARG FRSGSRPPGV SPGSSVSDVD
QEEPRFGAVA TVNLATGEGL PPLGSADGAL GPASRDSMVR HHAGSLALGE REAGGRILPS
TSHTHLDPTK GHKS
//
