ID H0XYD1_OTOGA Unreviewed; 789 AA.
AC H0XYD1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Cyclin-F {ECO:0000256|ARBA:ARBA00019493};
GN Name=CCNF {ECO:0000313|Ensembl:ENSOGAP00000021124.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021124.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000021124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000256|ARBA:ARBA00006955}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03078070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003790853.1; XM_003790805.1.
DR AlphaFoldDB; H0XYD1; -.
DR STRING; 30611.ENSOGAP00000021124; -.
DR Ensembl; ENSOGAT00000034742.1; ENSOGAP00000021124.1; ENSOGAG00000028205.1.
DR GeneID; 100960591; -.
DR KEGG; oga:100960591; -.
DR CTD; 899; -.
DR eggNOG; KOG0654; Eukaryota.
DR GeneTree; ENSGT00810000125541; -.
DR HOGENOM; CLU_020348_0_0_1; -.
DR InParanoid; H0XYD1; -.
DR OMA; HQAKKSC; -.
DR OrthoDB; 3020936at2759; -.
DR TreeFam; TF101006; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0010826; P:negative regulation of centrosome duplication; IEA:Ensembl.
DR GO; GO:0001890; P:placenta development; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd20521; CYCLIN_CCNF_rpt1; 1.
DR CDD; cd20522; CYCLIN_CCNF_rpt2; 1.
DR CDD; cd22082; F-box_FBXO1; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10177:SF496; CYCLIN-F; 1.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF00646; F-box; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS00292; CYCLINS; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 29..76
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 563..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 88373 MW; 8CFBB46989CE72C4 CRC64;
MGSGGVVHCR CAKCFCYPMK RRVRRRPRSL TILSLPEDVL FHILKWLSVG DILAIRAVHS
HLKYLVDNHA SVWACASFQE LWPSPKNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD
EGRAEVNGLK ASHFFSLSER LNAGAAPFVW LFIRPPWSVS GSCCKAVVHE SLRAECQLQR
THKASILHCL GRVLSLFEDE EKQQQARDLF EESANQGCLT SSYLLWESDR RTDMSDPGRC
LHSFRKLRDY AAKGCWEAQL SLAKACANGH QLGLETKVSS EIVCQLFQAS QAVSKQQVFS
VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY RLQLLGIACM
VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSV LEGKIRVPTV VDYKEVLLTL
VPTAPRTQHL CSFLCELSLL HTSLSTYTPA CLAATALLLA RLTHGQTQPW TTRLWELTGF
SYEDLIPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK RYEEISQEEV LSYGQLCATL
GVKQESPEPP SFLSTGDIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL
LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTL VYLNPEQHCC QESSDEEACP
EDKGGQDPHT PALGTQTPPN TGPEPPLQVR RELGKDSTTS GYSSLSSTSP TNSMDGSLGG
LPRPTSVLSL GSDSNTQPCH HQARKSCLQC HPLSPPESSV PWQQVKRKNL SMHSEEEEEE
DMNLGFLKL
//
