ID H0XYM4_OTOGA Unreviewed; 665 AA.
AC H0XYM4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Pyrin {ECO:0008006|Google:ProtNLM};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021217.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000021217.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03078218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XYM4; -.
DR STRING; 30611.ENSOGAP00000021217; -.
DR Ensembl; ENSOGAT00000025560.1; ENSOGAP00000021217.1; ENSOGAG00000028428.1.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000161955; -.
DR HOGENOM; CLU_016050_0_0_1; -.
DR InParanoid; H0XYM4; -.
DR OMA; CQRHMKQ; -.
DR TreeFam; TF351091; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19771; Bbox2_TRIM20; 1.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF606; PYRIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 443..480
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REGION 93..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 73738 MW; 1DE843F61541B274 CRC64;
MARTLSDHLL STLEELVPYD LEKFKFKLQN TSLEKEHSRI PRGQLQTARP VKVADLLVTY
YGEEYAVRLT LQVLRGINQR LLAEELHKVI SQEYPTQESN TDSSTASCST GENKSKNLKI
ADNPNIDHCN DRVATPPSSQ PEAGRGTLRK SLSKRRDLKG LECLEAQGKP WLRGTSLLHR
RGTGLSSVPG TPKASPGLRR NASSAGRLQG LSSGALGRKE SKKSEVHVYL PSGKKRPKSL
ELTIPSVERE LSHPETLLTQ EEIIPANPDK AAISRAVATL DVGATVAEEK DSQNLEHSGG
TFRNTLSSAL LAGEEKATVL WEKNGIGVPE IPETVEKMVD SVLHESSNPE VPESSSEKRP
QNPEDLASLG MVACKGSPPD KASNTLCYTQ EGDTVDGTCV QDSCICPVAS GDPEASGSRP
PSCLQCQARN NSGSLSPQLL PQCKRHLNQV QLLFCEDHEE PICLICRLSQ EHRGHQVRPI
EEAALDYKEQ IQKHLKHLKA LRKSGEEQKS QGATQMADFL KQTEIQKERM QSQREQLCQF
LEQQEKFFVA WLEELGQTIG QVRETYGTRV SRDIALLDSL IGELEAKQCQ SEWKLLQDIG
DTLHRAKTVP VPEPWTTPPE MKEKIYLLHQ KSEFVEKSMK YFSIPELISA QAHAGKCPDQ
GKWPG
//
