ID H0Y108_OTOGA Unreviewed; 339 AA.
AC H0Y108;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Lumican {ECO:0000256|ARBA:ARBA00013370};
GN Name=LUM {ECO:0000313|Ensembl:ENSOGAP00000022051.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000022051.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000022051.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Binds to laminin. {ECO:0000256|ARBA:ARBA00011719}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class II subfamily. {ECO:0000256|ARBA:ARBA00005818}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03016956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003783408.1; XM_003783360.2.
DR AlphaFoldDB; H0Y108; -.
DR STRING; 30611.ENSOGAP00000022051; -.
DR Ensembl; ENSOGAT00000026452.1; ENSOGAP00000022051.1; ENSOGAG00000025875.1.
DR GeneID; 100946463; -.
DR KEGG; oga:100946463; -.
DR CTD; 4060; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158177; -.
DR HOGENOM; CLU_000288_186_4_1; -.
DR InParanoid; H0Y108; -.
DR OMA; DCPINFP; -.
DR OrthoDB; 521898at2759; -.
DR TreeFam; TF334562; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005583; C:fibrillar collagen trimer; IEA:Ensembl.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032914; P:positive regulation of transforming growth factor beta1 production; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF6; LUMICAN; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01462; LRRNT; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 5.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..339
FT /note="Lumican"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003546558"
FT DOMAIN 37..71
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
SQ SEQUENCE 339 AA; 38571 MW; 50328AF210937C21 CRC64;
MNLGAFALCL ALIWGVSGQY YDDYDFPLSI YGLSSPNCAP ECNCPESYPS AMYCDQLKLK
SVPMVPPGIK YLYLRNNQID HIDDKAFENV TDLQWLILDH NLLENSKIKG RVFSKLKQLK
KLHINYNNLT ESVGPLPKSL EDLQLTNNKI TKLGSFEGLV NLTFIHLQHN LLREDAISAA
FRGLKSLEYL DLSFNQMSKL PSGLPVTLLT LYLDNNKINN IPDEYFKRFN GLQYLRLSHN
ELADGGIPGN SFNVSSLVEL DLSYNKLKSI PTVNENLENY YLEVNELEKF EVKSFCKILG
PLSYSKIKHL RLDGNRLTES SLPPDMYECL RVANEITVN
//
