ID H0Y9T6_HUMAN Unreviewed; 3006 AA.
AC H0Y9T6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=WD repeat and FYVE domain containing 3 {ECO:0000313|Ensembl:ENSP00000424987.2};
DE Flags: Fragment;
GN Name=WDFY3 {ECO:0000313|Ensembl:ENSP00000424987.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424987.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000424987.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3] {ECO:0000313|Ensembl:ENSP00000424987.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC095046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC108021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC110806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0Y9T6; -.
DR SMR; H0Y9T6; -.
DR MassIVE; H0Y9T6; -.
DR MaxQB; H0Y9T6; -.
DR PeptideAtlas; H0Y9T6; -.
DR ProteomicsDB; 36143; -.
DR Antibodypedia; 25252; 305 antibodies from 26 providers.
DR Ensembl; ENST00000514711.2; ENSP00000424987.2; ENSG00000163625.17.
DR UCSC; uc062xxg.1; human.
DR HGNC; HGNC:20751; WDFY3.
DR VEuPathDB; HostDB:ENSG00000163625; -.
DR GeneTree; ENSGT00940000155680; -.
DR HOGENOM; CLU_428713_0_0_1; -.
DR ChiTaRS; WDFY3; human.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000163625; Expressed in sural nerve and 203 other cell types or tissues.
DR ExpressionAtlas; H0Y9T6; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:H0Y9T6,
KW ECO:0007829|MaxQB:H0Y9T6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2011..2136
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2163..2456
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2603..2644
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 2934..2994
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1935..2006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2735..2793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1944..1958
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2754..2769
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2775..2793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000424987.2"
SQ SEQUENCE 3006 AA; 336849 MW; B549D4A8CD18ADCC CRC64;
FTRHDYIFKD VFREVGLLEV MVNLLHKYAA LLKDPTQALN EQGDSRNNSS VEDQKHLALL
VMETLTVLLQ GSNTNAGIFR EFGGARCAHN IVKYPQCRQH ALMTIQQLVL SPNGDDDMGT
LLGLMHSAPP TELQLKTDIL RALLSVLRES HRSRTVFRKV GGFVYITSLL VAMERSLSCP
PKNGWEKVNQ NQVFELLHTV FCTLTAAMRY EPANSHFFKT EIQYEKLADA VRFLGCFSDL
RKISAMNVFP SNTQPFQRLL EEDVISIESV SPTLRHCSKL FIYLYKVATD SFDSRAEQIP
PCLTSESSLP SPWGTPALSR KRHAYHSVST PPVYPPKNVA DLKLHVTTSS LQSSDAVIIH
PGAMLAMLDL LASVGSVTQP EHALDLQLAV ANILQSLVHT ERNQQVMCEA GLHARLLQRC
SAALADEDHS LHPPLQRMFE RLASQALEPM VLREFLRLAS PLNCGAWDKK LLKQYRVHKP
SSLSYEPEMR SSMITSLEGL GTDNVFSLHE DNHYRISKSL VKSAEGSTVP LTRVKCLVSM
TTPHDIRLHG SSVTPAFVEF DTSLEGFGCL FLPSLAPHNA PTNNTVTTGL IDGAVVSGIG
SGERFFPPPS GLSYSSWFCI EHFSSPPNNH PVRLLTVVRR ANSSEQHYVC LAIVLSAKDR
SLIVSTKEEL LQNYVDDFSE ESSFYEILPC CARFRCGELI IEGQWHHLVL VMSKGMLKNS
TAALYIDGQL VNTVKLHYVH STPGGSGSAN PPVVSTVYAY IGTPPAQRQI ASLVWRLGPT
HFLEEVLPSS NVTTIYELGP NYVGSFQAVC MPCKDAKSEG VVPSPVSLVP EEKVSFGLYA
LSVSSLTVAR IRKVYNKLDS KAIAKQLGIS SHENATPVKL IHNSAGHLNG SARTIGAALI
GYLGVRTFVP KPVATTLQYV GGAAAILGLV AMASDVEGLY AAVKALVCVV KSNPLASKEM
ERIKGYQLLA MLLKKKRSLL NSHILHLTFS LVGTVDSGHE TSIIPNSTAF QDLLCDFEVW
LHAPYELHLS LFEHFIELLT ESSEASKNAK LMREFQLIPK LLLTLRDMSL SQPTIAAISN
VLSFLLQGFP SSNDLLRFGQ FISSTLPTFA VCEKFVVMEI NNEEKLDTGT EEEFGGLVSA
NLILLRNRLL DILLKLIYTS KEKTSINLQA CEELVKTLGF DWIMMFMEEH LHSTTVTAAM
RILVVLLSNQ SILIKFKEGL SGGGWLEQTD SVLTNKIGTV LGFNVGRSAG GRSTVREINR
DACHFPGFPV LQSFLPKHTN VPALYFLLMA LFLQQPVSEL PENLQFDLDS IWTFIFGVPA
SSGTVVSSIH NVCTEAVFLL LGMLRSMLTS PWQSEEEGSW LREYPVTLMQ FFRYLYHNVP
DLASMWMSPD FLCALAATVF PFNIRPYSEM VTDLDDEVGS PAEEFKAFAA DTGMNRSQSE
YCNVGTKTYL TNHPAKKFVF DFMRVLIIDN LCLTPASKQT PLIDLLLEAS PERSTRTQQK
EFQTYILDSV MDHLLAADVL LGEDASLPIT SGGSYQVLVN NVFYFTQRVV DKLWQGMFNK
ESKLLIDFII QLIAQSKRRS QGLSLDAVYH CLNRTILYQF SRAHKTVPQQ VALLDSLRVL
TVNRNLILGP GNHDQEFISC LAHCLINLHV GSNVDGFGLE AEARMTTWHI MIPSDIEPDG
SYSQDISEGR QLLIKAVNRV WTELIHSKKQ VLEELFKVTL PVNERGHVDI ATARPLIEEA
ALKCWQNHLA HEKKCISRGE ALAPTTQSKL SRVSSGFGLS KLTGSRRNRK ESGLNKHSLS
TQEISQWMFT HIAVVRDLVD TQYKEYQERQ QNALKYVTEE WCQIECELLR ERGLWGPPIG
SHLDKWMLEM TEGPCRMRKK MVRNDMFYNH YPYVPETEQE TNVAKPARYR RAVSYDSKEY
YMRLASGNPA IVQDAIVESS EGEAAQQEPE HGEDTIAKVK GLVKPPLKRS RSAPDGGDEE
NQEQLQDQIA EGSSIEEEEK TDNATLLRLL EEGEKIQHMY RCARVQGLDT SEGLLLFGKE
HFYVIDGFTM TATREIRDIE TLPPNMHEPI IPRGARQGPS QLKRTCSIFA YEDIKEVHKR
RYLLQPIAVE VFSGDGRNYL LAFQKGIRNK VYQRFLAVVP SLTDSSESVS GQRPNTSVEQ
GSGLLSTLVG EKSVTQRWER GEISNFQYLM HLNTLAGRSY NDLMQYPVFP WILADYDSEE
VDLTNPKTFR NLAKPMGAQT DERLAQYKKR YKDWEDPNGE TPAYHYGTHY SSAMIVASYL
VRMEPFTQIF LRLQGGHFDL ADRMFHSVRE AWYSASKHNM ADVKELIPEF FYLPEFLFNS
NNFDLGCKQN GTKLGDVILP PWAKGDPREF IRVHREALEC DYVSAHLHEW IDLIFGYKQQ
GPAAVEAVNV FHHLFYEGQV DIYNINDPLK ETATIGFINN FGQIPKQLFK KPHPPKRVRS
RLNGDNAGIS VLPGSTSDKI FFHHLDNLRP SLTPVKELKE PVGQIVCTDK GILAVEQNKV
LIPPTWNKTF AWGYADLSCR LGTYESDKAM TVYECLSEWG QILCAICPNP KLVITGGTST
VVCVWEMGTS KEKAKTVTLK QALLGHTDTV TCATASLAYH IIVSGSRDRT CIIWDLNKLS
FLTQLRGHRA PVSALCINEL TGDIVSCAGT YIHVWSINGN PIVSVNTFTG RSQQIICCCM
SEMNEWDTQN VIVTGHSDGV VRFWRMEFLQ VPETPAPEPA EVLEMQEDCP EAQIGQEAQD
EDSSDSEADE QSISQDPKDT PSQPSSTSHR PRAASCRATA AWCTDSGSDD SRRWSDQLSL
DEKDGFIFVN YSEGQTRAHL QGPLSHPHPN PIEVRNYSRL KPGYRWERQL VFRSKLTMHT
AFDRKDNAHP AEVTALGISK DHSRILVGDS RGRVFSWSVS DQPGRSAADH WVKDEGGDSC
SGCSVRFSLT ERRHHCRNCG QLFCQKCSRF QSEIKRLKIS SPVRVCQNCY YNLQHERGSE
DGPRNC
//
