ID H0YBY4_HUMAN Unreviewed; 120 AA.
AC H0YBY4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Phospholipid phosphatase related 3 {ECO:0000313|Ensembl:ENSP00000430544.2};
DE Flags: Fragment;
GN Name=PLPPR3 {ECO:0000313|Ensembl:ENSP00000430544.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430544.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000430544.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000430544.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000256|ARBA:ARBA00008816}.
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DR EMBL; AC004799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0YBY4; -.
DR SMR; H0YBY4; -.
DR MassIVE; H0YBY4; -.
DR PeptideAtlas; H0YBY4; -.
DR ProteomicsDB; 36880; -.
DR Antibodypedia; 53515; 118 antibodies from 22 providers.
DR Ensembl; ENST00000517665.2; ENSP00000430544.2; ENSG00000129951.19.
DR UCSC; uc060qrl.1; human.
DR HGNC; HGNC:23497; PLPPR3.
DR VEuPathDB; HostDB:ENSG00000129951; -.
DR GeneTree; ENSGT00940000160280; -.
DR HOGENOM; CLU_2054997_0_0_1; -.
DR ChiTaRS; PLPPR3; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000129951; Expressed in cortical plate and 108 other cell types or tissues.
DR ExpressionAtlas; H0YBY4; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR PANTHER; PTHR10165; LIPID PHOSPHATE PHOSPHATASE; 1.
DR PANTHER; PTHR10165:SF14; PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 3; 1.
DR Pfam; PF01569; PAP2; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:H0YBY4,
KW ECO:0007829|ProteomicsDB:H0YBY4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..74
FT /note="Phosphatidic acid phosphatase type 2/haloperoxidase"
FT /evidence="ECO:0000259|Pfam:PF01569"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000430544.2"
FT NON_TER 120
FT /evidence="ECO:0000313|Ensembl:ENSP00000430544.2"
SQ SEQUENCE 120 AA; 12590 MW; DB123EC6617D27C8 CRC64;
DIHAILSARK TFPSQHATLS AFAAVYVSLL KPILVFAFAI AAGVCGLTQI TQYRSHPVDV
YAGFLIGAGI AAYLACHAVG NFQAPPAEKP AAPAPAKDAL RALTQRGHDS VYQQNKSVST
//
