ID H0YDG9_HUMAN Unreviewed; 276 AA.
AC H0YDG9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Remodeling and spacing factor 1 {ECO:0000313|Ensembl:ENSP00000433603.1};
DE Flags: Fragment;
GN Name=RSF1 {ECO:0000313|Ensembl:ENSP00000433603.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433603.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0007829|PubMed:17081983}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000433603.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3] {ECO:0007829|PubMed:19608861}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [4] {ECO:0007829|PubMed:28112733}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [5] {ECO:0000313|Ensembl:ENSP00000433603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP000580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0YDG9; -.
DR SMR; H0YDG9; -.
DR MassIVE; H0YDG9; -.
DR MaxQB; H0YDG9; -.
DR PeptideAtlas; H0YDG9; -.
DR ProteomicsDB; 37392; -.
DR Antibodypedia; 31265; 135 antibodies from 30 providers.
DR Ensembl; ENST00000531026.5; ENSP00000433603.1; ENSG00000048649.14.
DR UCSC; uc058fue.1; human.
DR HGNC; HGNC:18118; RSF1.
DR VEuPathDB; HostDB:ENSG00000048649; -.
DR GeneTree; ENSGT00530000064411; -.
DR HOGENOM; CLU_1010220_0_0_1; -.
DR OMA; MTDHCEK; -.
DR ChiTaRS; RSF1; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000048649; Expressed in calcaneal tendon and 198 other cell types or tissues.
DR ExpressionAtlas; H0YDG9; baseline and differential.
DR GO; GO:0031213; C:RSF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15543; PHD_RSF1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028938; Rsf1-like.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14296; REMODELING AND SPACING FACTOR 1; 1.
DR PANTHER; PTHR14296:SF3; REMODELING AND SPACING FACTOR 1; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:H0YDG9,
KW ECO:0007829|MaxQB:H0YDG9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 1..50
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 92..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..220
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..247
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..276
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000433603.1"
FT NON_TER 276
FT /evidence="ECO:0000313|Ensembl:ENSP00000433603.1"
SQ SEQUENCE 276 AA; 31953 MW; 79AF03734BFC371D CRC64;
EPCKKCGLPN HPELILLCDS CDSGYHTACL RPPLMIIPDG EWFCPPCQHK LLCEKLEEQL
QDLDVALKKK ERAERRKERL VYVGISIENI IPPQEPDFSE DQEEKKKDSK KSKANLLERR
STRTRKCISY RFDEFDEAID EAIEDDIKEA DGGGVGRGKD ISTITGHRGK DISTILDEER
KENKRPQRAA AARRKKRRRL NDLDSDSNLD EEESEDEFKI SDGSQDEFVV SDENPDESEE
DPPSNDDSDT DFCSRRLRRH PSRPMRQSRR LRRKTP
//
