ID H0YNB5_HUMAN Unreviewed; 216 AA.
AC H0YNB5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Furin, paired basic amino acid cleaving enzyme {ECO:0000313|Ensembl:ENSP00000453942.1};
DE Flags: Fragment;
GN Name=FURIN {ECO:0000313|Ensembl:ENSP00000453942.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453942.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000453942.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000453942.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; AC124248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0YNB5; -.
DR SMR; H0YNB5; -.
DR MassIVE; H0YNB5; -.
DR MaxQB; H0YNB5; -.
DR PeptideAtlas; H0YNB5; -.
DR ProteomicsDB; 40510; -.
DR Ensembl; ENST00000558794.1; ENSP00000453942.1; ENSG00000140564.13.
DR UCSC; uc059ngp.1; human.
DR HGNC; HGNC:8568; FURIN.
DR VEuPathDB; HostDB:ENSG00000140564; -.
DR GeneTree; ENSGT00940000157220; -.
DR HOGENOM; CLU_068978_1_0_1; -.
DR OMA; FREWAFM; -.
DR ChiTaRS; FURIN; human.
DR Proteomes; UP000005640; Chromosome 15.
DR Bgee; ENSG00000140564; Expressed in right lobe of liver and 192 other cell types or tissues.
DR ExpressionAtlas; H0YNB5; baseline and differential.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR PANTHER; PTHR42884:SF1; FURIN; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Proteomics identification {ECO:0007829|EPD:H0YNB5,
KW ECO:0007829|MaxQB:H0YNB5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 1..184
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000453942.1"
SQ SEQUENCE 216 AA; 23150 MW; 276A707455168D30 CRC64;
PNHIHIYSAS WGPEDDGKTV DGPARLAEEA FFRGVSQGRG GLGSIFVWAS GNGGREHDSC
NCDGYTNSIY TLSISSATQF GNVPWYSEAC SSTLATTYSS GNQNEKQIVT TDLRQKCTES
HTGTSASAPL AAGIIALTLE ANKNLTWRDM QHLVVQTSKP AHLNANDWAT NGVGRKVSHS
YGYGLLDAGA MVALAQNWTT VAPQRKCIID ILTEPK
//