ID H0YSB7_TAEGU Unreviewed; 635 AA.
AC H0YSB7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein {ECO:0000256|ARBA:ARBA00040699};
DE AltName: Full=APBB1-interacting protein 1 {ECO:0000256|ARBA:ARBA00042746};
GN Name=APBB1IP {ECO:0000313|Ensembl:ENSTGUP00000001177.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000001177.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000001177.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000001177.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MRL family. {ECO:0000256|ARBA:ARBA00038382}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H0YSB7; -.
DR STRING; 59729.ENSTGUP00000031108; -.
DR Ensembl; ENSTGUT00000001189.2; ENSTGUP00000001177.2; ENSTGUG00000001140.2.
DR GeneTree; ENSGT00940000156105; -.
DR HOGENOM; CLU_023207_2_0_1; -.
DR TreeFam; TF317511; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16137; RA_MRL_RIAM; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243:SF14; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 148..235
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 278..387
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 119..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..588
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 70237 MW; 3438B45388363F18 CRC64;
MEQTCDDIDE MFSNLLGEMD MLTQSLGVET VPPPCPKVSN SEFSFTVGFK DLNESLNALE
DKDLDALMAD LVADLNDVEQ KTLQAQKMSS CNQQSTVTQP SIGLNDGIYS KVSPYVSIIG
QSGDDLPPPP PPPDPEPELP PPPPPPPPEP LTQVHMNDNS TKSLMVDERQ VARDVLDNLF
EKTHCDCNVD WCLYEMYPEL QIERFFEDHE NVVEVLSDWT RDTENKVLFL EKSQKYALFK
NPQNFYLANK GKKESKEMND KNKEALLEES FCGTSVIVPE LEGALYLKED GKKSWKRRYF
LLRASGIYYV PRGKTKTSRD LACFLQFENV NVYYGYQHKV KYKAPTDHCF VLKHPQIQKE
SQYIKYLCCD DKATLHQWVT GIRIAKYGKT LYDNYKCAVK KAGLSSRWAN QKVVEPAAPA
GSSSAGTVQS NGQIPQSIHH SSTELPDSQK KVDTSEAQAA RNNASAPGLA QPLLKPQKVQ
SKRTSLQPPP PPERRSSVIS ASPVLPSKVK RDSGIFLTDP ENFPAPPPSL KIDFPPPPPP
DFCEPPPDFV PPPPPVSSSS NGDVPLPPPP PPVSSQPPPP PVKKPVPLPP KRLENTGQGG
EPQSAGLPLI AGGSKQADFM SDLMKALEKK RGNTS
//
