ID H0Z6C1_TAEGU Unreviewed; 397 AA.
AC H0Z6C1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Sorting nexin {ECO:0000256|PIRNR:PIRNR036924};
GN Name=SNX5 {ECO:0000313|Ensembl:ENSTGUP00000006119.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000006119.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000006119.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000006119.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in several stages of intracellular trafficking.
CC {ECO:0000256|PIRNR:PIRNR036924}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883, ECO:0000256|PIRNR:PIRNR036924}.
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DR RefSeq; XP_002198957.1; XM_002198921.3.
DR AlphaFoldDB; H0Z6C1; -.
DR STRING; 59729.ENSTGUP00000006119; -.
DR Ensembl; ENSTGUT00000006178.2; ENSTGUP00000006119.2; ENSTGUG00000005916.2.
DR GeneID; 100223918; -.
DR KEGG; tgu:100223918; -.
DR CTD; 27131; -.
DR GeneTree; ENSGT00940000154632; -.
DR HOGENOM; CLU_040966_0_0_1; -.
DR InParanoid; H0Z6C1; -.
DR OMA; ICAEDST; -.
DR OrthoDB; 5398040at2759; -.
DR TreeFam; TF313698; -.
DR Proteomes; UP000007754; Chromosome 3.
DR GO; GO:0098559; C:cytoplasmic side of early endosome membrane; IEA:Ensembl.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070685; C:macropinocytic cup; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0097422; C:tubular endosome; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006907; P:pinocytosis; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR CDD; cd07663; BAR_SNX5; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR028654; BAR_SNX5.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014637; SNX5/SNX6/SNX32.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR45850:SF5; SORTING NEXIN-5; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036924};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036924}.
FT DOMAIN 19..166
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 397 AA; 45864 MW; DE2A64B94CDFBB92 CRC64;
MALLRGDAQD KLRSVSVDLN VDPSLQIDIP DALSEKDRVK FTVHTKTTLP AFQSPEFSVT
RQHEDFVWLH DTLTETEEYA GLIIPPAPSK PDFDGPREKM QKLGEGEVSM TKEEFAKMKQ
ELEAEYLAVF KKTVSSHEIF LQRIASHPVL SKDRNFHVFL EYDQDLSVRR KNTKEMFGGF
LKSVVKSADE VLFSGVKEVE DFFEQEKTFL VNYYNRIKDA CAKADKMTRS HKNVADDYIY
TSACLNSLAL EEPTVIKKYL LKVAELFEKL RKVESRVSSD EDLKLSELLR YYMLNIEAAK
DLLYRRTRAL VDYENSNKAL DKARLKSKDV RLAEAHQQDC CQKFEKISES AKQELMSFKQ
KRIAAFRKNL IEMAELEIKH AKNNVSLLQS CIDLFKN
//
