ID H0ZAZ2_TAEGU Unreviewed; 1066 AA.
AC H0ZAZ2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Small G protein signaling modulator 1 {ECO:0000313|Ensembl:ENSTGUP00000007749.2};
GN Name=SGSM1 {ECO:0000313|Ensembl:ENSTGUP00000007749.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007749.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007749.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007749.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RUTBC family.
CC {ECO:0000256|ARBA:ARBA00034124}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H0ZAZ2; -.
DR STRING; 59729.ENSTGUP00000007749; -.
DR Ensembl; ENSTGUT00000007830.2; ENSTGUP00000007749.2; ENSTGUG00000007521.2.
DR GeneTree; ENSGT00940000156871; -.
DR HOGENOM; CLU_006235_0_0_1; -.
DR InParanoid; H0ZAZ2; -.
DR OMA; EKWLAMH; -.
DR TreeFam; TF318216; -.
DR Proteomes; UP000007754; Chromosome 15.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR CDD; cd15784; PH_RUTBC; 1.
DR CDD; cd17703; RUN_SGSM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.230; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047344; RUN_SGSM1.
DR InterPro; IPR037745; SGSM1/2.
DR InterPro; IPR021935; SGSM1/2_RBD.
DR PANTHER; PTHR22957:SF187; SMALL G PROTEIN SIGNALING MODULATOR 1; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12068; PH_RBD; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 11..165
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 536..999
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 352..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..86
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 619..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1066 AA; 119860 MW; 50A695AB87FA38B6 CRC64;
MEEAVTRKFV HEDSSHIISF CAAVECCVLF GLKRRAAGFL RSNKIAALFM KVGKSFPLAE
ELCRKVQDLE QLIENARNQA QGVPENVRKV PKLPNLSPQA IKHLWIRTAL FEKVLDKIVH
YLVENSSKYY EKEALLMDPV DGPILASLLV GPCALEYTKM KTADHFWTDP SADELVQRHR
IHSSHCRQDS PTKRPALCIQ KRHSSGSMDD RPSLSARDYV ESLHQNSRAT LLYGKNNVLV
QPRDDMEAIP GYLSLHQTAD IMALKWTPNQ LMNGSVGDLD YEKSVYWDYA MTIRLEEIVY
LHCHQQVDSG GTVVLVSQDG IQRPPLRFPR GGHLLQFLSC LENGLLPHGQ LDPPLWSQRG
KGKVFPKLKK RSPQGSSESA SDKEDDEATD YVFRIIYPGT QMEFVPQDLM DAPGAVLPPM
WQPSTRKSSC SSCSQSGSSD GGPANGCSHE RAPLKLLCDN MKYQILSRAF YGWLAYCRHL
STVRTHLSAL VNHSIVSPDV PCSASEGLTV DIWHRYLQDS SSYEDQELLR LIYYGGIQHE
IRKAVWPFLL GHYQFGMTEA ERKEADEQTR ACYEHTMAEW LGCEAIVRQR EKESHAAALA
KCSSGASLDS HIQRMMHRDS TISNESSQSC SSGRQNHARL QSDSSSSTQV FESVDEVEQT
EVDSQLEDGK QSKIPNGTVP NGTCSPDSGH PSSQNFSITS GFSERSFSNE DSALETTKSS
SSSQGKAAGS DVPAPPDTDG VQQEKLQGQD SLEGEFPTGG SVDFVPMGSG SAGLLRDGDA
VALTVVESWA DSEAEKQSLV ESEDNLSEEP EMESLYPQLD SLTVTDLTSS EPAALSSTGV
TYSPELLDMY TVNLHRIEKD VQRCDRNYWY FTPANLEKLR NVMCSYIWQH IEIGYVQGMC
DLLAPLLVIL DDEALAFSCF TELMKRMNQN FPHGGAMDTH FANMRSLIQI LDSELFELMH
QNGDYTHFYF CYRWFLLDFK RELVYDDVFA VWETIWAAAH VSSAHYVLFI ALALVEMYRD
IILENNMDFT DIIKFFNEMA ERHNTKQILK LARDLVYKVQ TLIENK
//
