ID H0ZK52_TAEGU Unreviewed; 612 AA.
AC H0ZK52;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Apoptosis inducing factor mitochondria associated 3 {ECO:0000313|Ensembl:ENSTGUP00000010972.2};
GN Name=AIFM3 {ECO:0000313|Ensembl:ENSTGUP00000010972.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010972.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000010972.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000010972.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00006442}.
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DR AlphaFoldDB; H0ZK52; -.
DR STRING; 59729.ENSTGUP00000010972; -.
DR Ensembl; ENSTGUT00000011087.2; ENSTGUP00000010972.2; ENSTGUG00000010632.2.
DR GeneTree; ENSGT00940000160448; -.
DR HOGENOM; CLU_003291_4_2_1; -.
DR InParanoid; H0ZK52; -.
DR OMA; RCTHYGA; -.
DR TreeFam; TF314028; -.
DR Proteomes; UP000007754; Chromosome 15.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0097194; P:execution phase of apoptosis; IEA:Ensembl.
DR CDD; cd03478; Rieske_AIFL_N; 1.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR028202; Reductase_C.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR PANTHER; PTHR43557:SF8; APOPTOSIS-INDUCING FACTOR 3; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF14759; Reductase_C; 1.
DR Pfam; PF00355; Rieske; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
DR SUPFAM; SSF50022; ISP domain; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 70..165
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
SQ SEQUENCE 612 AA; 67751 MW; DB639DA7E0E812A8 CRC64;
MGGCFSKPKP VEVKIEVVIP EKERSKEEMS PNGKASPLIY KVNGTARHYH LEEHPIASNP
YHNPKDVVEA SVCHVKDLEN GQMREVDLGC GKALLIKESG EFHAVGHKCP HYGAPLVKGV
LSKGRVRCPW HGACFNISTG DIEDFPGLDS LPRFQVKIEK EKVYIRASKQ TLQTQRRTKM
MAKCISLSNY NLSSTNVLII GAGAAGLVCA ETLRQEGFSD RIVMCTMDRH LPYDRPKLSK
SMDSHPEQIA LRPKEFFCTY DIEVLTEMQV AAVDVKSKIA VFKDGFKMEY NKLLIATGST
PKTLSCKGKE MENVFNIRTP EDANRVVKLA TSKNVVIVGA SFLGMEVAAY LAERAHSVSL
VELEHVPFKK FFGERVGRAV MKMFENNRVK FYMQTEVSEL REQEGKLKEV VLKSGKVLRA
DVCVVGIATF GFTPGAVPAT GFLKQSGINI DSKGFIVVNK MMQTNIPGVF AAGDAVTFPL
ALRNNKKVNV PHWQMAHMHG RIAALNMLAH GTEISTVPYL WTAMFGKSIR YAGHGEGFDD
VVIQGDLDEL KFVAFYTKSD EVVAVASMNY DPIVSKVAEV LAAGRTIRKR DVELFVRHGK
TGDMSWLTGK GT
//
