ID H1LUI8_9FIRM Unreviewed; 1235 AA.
AC H1LUI8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HMPREF9099_01122 {ECO:0000313|EMBL:EHO52937.1};
OS Lachnospiraceae bacterium oral taxon 082 str. F0431.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=861454 {ECO:0000313|EMBL:EHO52937.1, ECO:0000313|Proteomes:UP000003005};
RN [1] {ECO:0000313|EMBL:EHO52937.1, ECO:0000313|Proteomes:UP000003005}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0431 {ECO:0000313|EMBL:EHO52937.1,
RC ECO:0000313|Proteomes:UP000003005};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHO52937.1}.
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DR EMBL; AGRL01000068; EHO52937.1; -; Genomic_DNA.
DR AlphaFoldDB; H1LUI8; -.
DR PATRIC; fig|861454.3.peg.1067; -.
DR eggNOG; COG0286; Bacteria.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_007510_1_0_9; -.
DR Proteomes; UP000003005; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 1235 AA; 143124 MW; 7E4831CE477FBAA2 CRC64;
MNKTAIKNFA IQARNKLIAD ISYRAGLMGI TTEGISEALP QSTPGTEFYD IGTDTPYSIS
GDAIAQRRKL VEVIRQKERD SDYATAYKYI IEEVAYTWFN RLIAIRFMEV NDYLPSRTRV
LSSIKGRIEP DIIASPFEAG FEFTDEEKEK ILQLKTDNQI DKLFCILFIK QCNALNEQLS
ALFEKTNDYT ELLLNISVID QDGVVYKLVH DISEDDFNIE KGGQVEIIGW LYQYYNTEPK
AEVFGRPSGT KIKKEDVPAA TQLFTPDWIV RYMVENSLGR LWVEGHPNDE LKSNWKYYLE
EAEQEPCVEE KLAEIRKEYA ELNPEDIKII DPCMGSGHIL VYAFDVLMQI YESAGYGQRD
TAVSILKNNI YGLDIDERAF QLSYFAVMMK ARQYNRRILN GEHRPNLYSI EESNSINRNH
LKYFGMSLSE SDREKALSQM NSLLDTFIDA KEYGSILTVK EYDFKLLEIF VSDNEPTGQI
SLETVGIEDT KEALLQLIAQ GKVLGQKYWV AVTNPPYIGI SNVGGDLYDL VCDKYNSFKQ
DLYCVFMKKV NDFTRLYGYQ AMITQQSFMF NSRFEKVRDW LLSSCVLKNL VYLDTGAFEE
ISGEKVRSCS FILLKNKFIN YKSKFIDLRN IDDAVKKEVI YRETCKKTSA ELLHLVKIDS
FKKIDGYCFS YWLSNKTIEI LGGKESLKKY AETRHGLVTG NGDLFMRLWY EVCFNNISFN
ESEECIWFPY NKGGSFRRWY GNREYIVNWK NDGESIRNYR DNNDCIKSSN YNDGYNFKEN
ISWSDIRSGK ISFRYTPKGA LFDTSGPSMI MIEQDKLYEL LGFLNTKVMQ KLIDVFCTGL
HYATGAVEKI PIIKIDLIEV RSLALECVSN TKSDWDSYET SWDFKYHPLV NHTNIDTDKP
VTVENSYKYW KSECEQRFTK LKANEEELNR IFIDIYGLQD ELTPEVLDKD ITVHRVFDTK
EDIPESMKGS AYIRTRRDEI VSLLSYAVGC MFGRYSLDTQ GLAYAGGEWD ASKYTSFKPV
LDDIIPITDE VYLEDDIDII TRLCTWLKVV YSENTLEENL DFIAKALGNK GNTSREIIRN
YFLNDFFKDH CQTYSVTGSG KRPIYWLFDS GKQNGFKALI YLHRYNADTV GNLRIDYLHR
MQRIYESEIE RMQNPVDHVA NARDVAAAKK RKEKLQKQLK ECREYDEKIA HLALSRIELD
LDDGVKVNYR KIQTGADGKF YEVLADSKNI MSKER
//
