ID H1VE99_COLHI Unreviewed; 793 AA.
AC H1VE99;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Rad4 transglutaminase-like domain-containing protein {ECO:0000313|EMBL:CCF38552.1};
GN ORFNames=CH063_09612 {ECO:0000313|EMBL:CCF38552.1};
OS Colletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum destructivum species complex.
OX NCBI_TaxID=759273 {ECO:0000313|EMBL:CCF38552.1, ECO:0000313|Proteomes:UP000007174};
RN [1] {ECO:0000313|Proteomes:UP000007174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMI 349063 {ECO:0000313|Proteomes:UP000007174};
RX PubMed=22885923; DOI=10.1038/ng.2372;
RA O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J.,
RA Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J.,
RA Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z.,
RA Choi J., Crouch J.A., Duvick J.P., Farman M.A., Gan P., Heiman D.,
RA Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y.,
RA Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U.,
RA Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H.,
RA Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L.,
RA Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K.,
RA Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F.,
RA van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J.,
RA Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E.,
RA Ma L.-J., Vaillancourt L.J.;
RT "Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered
RT by genome and transcriptome analyses.";
RL Nat. Genet. 44:1060-1065(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; CACQ02003033; CCF38552.1; -; Genomic_DNA.
DR AlphaFoldDB; H1VE99; -.
DR STRING; 759273.H1VE99; -.
DR EnsemblFungi; CCF38552; CCF38552; CH063_09612.
DR VEuPathDB; FungiDB:CH63R_06378; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_1_0_1; -.
DR Proteomes; UP000007174; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF3; DNA REPAIR PROTEIN RAD4; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 461..518
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 520..583
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 590..666
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 33..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 793 AA; 88598 MW; D2E1E55F9017DF3B CRC64;
MAGRKRTRVS RSRAAKSDVL DVYQEMLAEA TTDTGLSTSV EPPAKRLKRP GERKMEAGIA
TTSMEAGGVD EDEAQGIEFE DVTLPQATIQ TMYRDSEDDD DEEEEDDDDD EELKFENIDF
ATMQPESDAR EEPQTLTLNL SEHGGTKAGI QKRTMKRKPI TKEEKERRIF THRTHLLCLI
LHCALRNRWC NDEQAQRSLR PLLSKKTINY LTPGPSLPQF GQTESLKNGL QQAGSMFKSK
FQITERGLRR PLWAEDPKHL DNYELPANMD SCLNRSDFRD AARKLCGSRD VGAQLYCALL
RSVGVRARLV CSLQPLSFVH GGPNLPKPRS IETPIKPTRE DKIRTQLSRY RAVADESPSS
ASGLTSPLRR LGHPNAAAYQ LPLLSTPPPA AQKSKETPKR IHESPFPVYW VEVLDVGHQK
WQPTAVDRGD RWWRKALEPF ALPWPTDLDQ IEDNELNATE GREPMPRNVA DFKDHPVFAL
ERHLRRNEVL IPGSQPAGTV AAGSRAPLEK VYRRKDVRIA RSRDKWYRMG REVKPMEVPV
KFLPRRSNTK PGDYVDDGYG GDERNAAGTP VFTQEQTEVY HAPPVVNGRV PKNKFGNIDV
YVASMVPEGG VHIHDEFDTA VRAACMLGID YAPALSGFQF KGKQGTAVFN GVVVAQEYEL
AVRAVMGGFE DMDAQAELNK RSLAALHTWR RFLVALRIRE RVWAGADAEE RAEEERRLVG
SVEVDTTGVG SILDGDSETS HGGRCGDEDG DGTEDGAGFE LEPHDNMLED APSDVTEEYD
MVDDEGGGGF LVD
//
