ID H2C7K1_9CREN Unreviewed; 437 AA.
AC H2C7K1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=MetMK1DRAFT_00025500 {ECO:0000313|EMBL:EHP68127.1};
OS Metallosphaera yellowstonensis MK1.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Metallosphaera.
OX NCBI_TaxID=671065 {ECO:0000313|EMBL:EHP68127.1, ECO:0000313|Proteomes:UP000003980};
RN [1] {ECO:0000313|EMBL:EHP68127.1, ECO:0000313|Proteomes:UP000003980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MK1 {ECO:0000313|EMBL:EHP68127.1,
RC ECO:0000313|Proteomes:UP000003980};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Cheng J.-F., Goodwin L., Pitluck S., Peters L.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Kozubal M., Macur R.E., Jay Z., Inskeep W., Woyke T.;
RT "Improved High-Quality Draft sequence of Metallosphaera yellowstonensis
RT MK1.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR EMBL; JH597770; EHP68127.1; -; Genomic_DNA.
DR RefSeq; WP_009074240.1; NZ_JH597770.1.
DR AlphaFoldDB; H2C7K1; -.
DR STRING; 671065.MetMK1DRAFT_00025500; -.
DR eggNOG; arCOG01749; Archaea.
DR HOGENOM; CLU_021594_4_1_2; -.
DR OrthoDB; 26319at2157; -.
DR Proteomes; UP000003980; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF22; FUMARATE HYDRATASE CLASS II; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000003980}.
FT DOMAIN 2..315
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 381..431
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 437 AA; 47344 MW; 940DFDD17575EDFB CRC64;
MKYTETAPKL FMNTGTKFHR SIIWAMGVVK LAAARANASL GLLDSRVAEG IEKAAREIME
GNLDNLITLD VFQTGSGTGL NMNVNEVIAE RASQLTGLRV HPNDHVNMGQ SSNDTVPTAI
RIAATKQVVE KLRPALTEIV TSLRSKGDEY ASVVKAGRTH LRDAMPVTFG QELHAYADAF
DHDISLLSST LEYVKELPLG GTATGTGANS HPKFRELAIQ MINEVTGLSF KPGHTFRGMR
FLTDLLTLSG VMRTVAVELF RVAQDFRLMF SGPFTAIGEI DLPTQEEIAG SSIMPGKTNP
VTVEASMLIS AQVIGLDHAN QFASSLGEFE LAMGVPLIGQ NVVTQVDLLS EGLNKFNQLV
IKGVVPNVDR MRRYAESSPA LVTAISPLVG YDKASQIGKM LIKGMSIREA LKELGIDNSK
IDEILDLRKL VKPGLQK
//
