ID H2CJI0_9LEPT Unreviewed; 681 AA.
AC H2CJI0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Ammonium transporter {ECO:0000256|RuleBase:RU362002};
GN ORFNames=Lepil_2462 {ECO:0000313|EMBL:EHQ07137.1};
OS Leptonema illini DSM 21528.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptonema.
OX NCBI_TaxID=929563 {ECO:0000313|EMBL:EHQ07137.1, ECO:0000313|Proteomes:UP000005737};
RN [1] {ECO:0000313|EMBL:EHQ07137.1, ECO:0000313|Proteomes:UP000005737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21528 {ECO:0000313|EMBL:EHQ07137.1,
RC ECO:0000313|Proteomes:UP000005737};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E.-M.,
RA Klenk H.-P., Eisen J.A.;
RT "The Improved High-Quality Draft genome of Leptonema illini DSM 21528.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC family. {ECO:0000256|ARBA:ARBA00005887, ECO:0000256|RuleBase:RU362002}.
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DR EMBL; JH597773; EHQ07137.1; -; Genomic_DNA.
DR RefSeq; WP_002772869.1; NZ_JH597773.1.
DR AlphaFoldDB; H2CJI0; -.
DR STRING; 183.GCA_002009735_03267; -.
DR HOGENOM; CLU_000445_33_6_12; -.
DR Proteomes; UP000005737; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR001905; Ammonium_transpt.
DR InterPro; IPR018047; Ammonium_transpt_CS.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR NCBIfam; TIGR00836; amt; 1.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF6; AMMONIUM TRANSPORTER; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS01219; AMMONIUM_TRANSP; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Ammonia transport {ECO:0000256|ARBA:ARBA00023177,
KW ECO:0000256|RuleBase:RU362002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362002}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 49..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 264..283
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 289..306
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 318..339
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 351..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT DOMAIN 505..632
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 681 AA; 72988 MW; 737AB5207942A396 CRC64;
MDRSAADILW ILISAGLVLL MQAGFLAIES GLTRSKNSIN VAIKNITDFG VAAIFFWVAG
FALMFGTSVA GLFGSDHFLL SWSPSDMWTP AFFVFQLAFA GTSATIVSGA VAERFRFQAY
IITTALISCV IYPLAGHWAW GSAYGPSTPG WLESLGFVDF AGSTIVHSVG GWVSLAALLV
TGPRSGRFVE GQPPRIINGS NLPMAMLGGI ILWVGWVGFN GGSTLALDVR IAGIIANTVL
ALGAGLVTSL LLTWLRLGFA EATAPLNGSL AGLVAVTAGA HALSPVSALF VGAVAGLLVM
PTISLLERLR IDDAVGAVPV HLISGIWGTL AVGLFGDAAA LGTGLGRLEQ IAVQLTGIVA
IGVWAFGFSY LLLKGIDRFF PLRVTLEDEK AGLNISEHRA STDLVDLLVV MEQQKHSGDL
SSGVPVEPFT EVGQIAEMYN SVLHRVRSTL QENEEARLEI GKAYEKAQEE HKRAESLLLN
ILPPTIAEQL KSRSGIIANS FSSATVLFAD IVGFTQLASK YSPEVLVRML NRIFSAFDAT
LDRLGLEKIK TIGDSYMAVA GLPNERPDHA AVVVEFALRI QEIMKKFRFR DDSIIEMRVG
ISSGPVVAGI IGTKRFIYDL WGETVNLASR MESAGLPGEV QISEETARLL ENRFAIEERG
LLDLKGIGER RAFLVRGRRE G
//
