ID H2D5E7_CHICK Unreviewed; 732 AA.
AC H2D5E7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AEX25761.1};
RN [1] {ECO:0000313|EMBL:AEX25761.1}
RP NUCLEOTIDE SEQUENCE.
RA Ruan W., Wu Y., Zheng S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEX25761.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22184434;
RA Ruan W.K., Wu Y.H., An J., Cui D.F., Li H.R., Zheng S.J.;
RT "Toll-like receptor 2 type 1 and type 2 polymorphisms in different chicken
RT breeds.";
RL Poult. Sci. 91:101-106(2012).
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; JN544176; AEX25761.1; -; mRNA.
DR AlphaFoldDB; H2D5E7; -.
DR VEuPathDB; HostDB:geneid_769014; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 2.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..732
FT /note="Toll-like receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003561093"
FT TRANSMEM 537..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 587..730
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 732 AA; 83633 MW; D2963AA482FF2FD7 CRC64;
MHTWKMWAIC TALAAYLPEE QALRQACLSC DATQSCNCSF MGLDFIPPGL TGKITVLNLA
HNRIKVIRTH DLQKAVNLRT LLLQSNQISS IDEDSFGSQG KLELLDLSNN SLAHLSPVWF
GPLFSLQHLR IQGNSYSDLG ESSPFSSLRN LSSLHLGNPQ FSIIRQGNFE GIVFLNTLRI
DGDNLSQYEP GSLKSIRKIN HMIISIRRID VFSAVIRDLL HSAIWLDVRK LAFSVPEKIQ
LLRIMSSSFA KKISLKQCLF TDATVPEIVS ILEGMPKLME VEMKDCTLLG TGKWYKQIHA
NQSQSLRILT IENLSIEEFY LFTDLQSVLD LLSLFRKVTV ENTKVFLVPC KLSQHLLSLE
YLDLSANLLG DQSLEHSACQ GAWPSLQTLN LSQNSLSDLK MTGKSLFHLR NLNLLDISEN
NFGEIPDMCE WPENLKYLNL SSTQIPKLTT CIPSTLEVLD VSANNLQDFG LQLPFLKELY
LTKNHLKTLP EATDIPNLVA MSISRNKLNS FSKEELTVRG AQVGSVQLSL MECHRSLLVS
LICTLVFLFI LILVVVGYKY RAVWYMRMTW AWLQAKRKPK RAPTKDICYD AFVSYSENDS
NWVENIMVQQ LEQACPPFRL CLHKRDFVPG KWIVDNIIDS IEKSHKTLFV LSEHFVQSEW
CKYELDFSHF RLFDENNDVA ILILLEPIQS QAIPKRFCKL RKIMNTKTYL EWPPDEEQQQ
MFWENLKAAL KS
//
