ID   H2D740_STRSL            Unreviewed;       226 AA.
AC   H2D740;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=UDP-N-acetylglucosamine kinase {ECO:0000256|ARBA:ARBA00011963};
DE            EC=2.7.1.176 {ECO:0000256|ARBA:ARBA00011963};
DE   AltName: Full=UDP-N-acetylglucosamine kinase {ECO:0000256|ARBA:ARBA00032897};
OS   Streptococcus salivarius.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1304 {ECO:0000313|EMBL:AEX55145.1};
RN   [1] {ECO:0000313|EMBL:AEX55145.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=5M6c {ECO:0000313|EMBL:AEX55145.1};
RX   PubMed=22101034; DOI=10.1128/AEM.06588-11;
RA   Birri D.J., Brede D.A., Nes I.F.;
RT   "Salivaricin D, a Novel Intrinsically Trypsin-Resistant Lantibiotic from
RT   Streptococcus salivarius 5M6c Isolated from a Healthy Infant.";
RL   Appl. Environ. Microbiol. 78:402-410(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-
CC         acetyl-alpha-D-glucosamine 3'-phosphate; Xref=Rhea:RHEA:32671,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:64353, ChEBI:CHEBI:456216; EC=2.7.1.176;
CC         Evidence={ECO:0000256|ARBA:ARBA00000912};
CC   -!- SIMILARITY: Belongs to the zeta toxin family.
CC       {ECO:0000256|ARBA:ARBA00009104}.
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DR   EMBL; JN564797; AEX55145.1; -; Genomic_DNA.
DR   AlphaFoldDB; H2D740; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010488; Zeta_toxin_domain.
DR   PANTHER; PTHR39206; SLL8004 PROTEIN; 1.
DR   PANTHER; PTHR39206:SF1; SLL8004 PROTEIN; 1.
DR   Pfam; PF06414; Zeta_toxin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649}.
FT   DOMAIN          27..183
FT                   /note="Zeta toxin"
FT                   /evidence="ECO:0000259|Pfam:PF06414"
SQ   SEQUENCE   226 AA;  25879 MW;  57C82E5EB49B2756 CRC64;
     MDSKAYAKEH KQAFIAKVVK GKVPVLEEKL AIFMAGTPGA GKTEVVESLM EFANDEELCV
     IDSDRFRAQF PGYNGSNSSD FQPGATYLVN TTFDYLLKEG YSFILDGTFG AHQDVVIRNV
     KRALKRDYHV ILCFVYQEPL RAWLFTKSRT KLEGRKVPKE VFIRSYVQMI DNLSIVKETF
     NDAISYRVVD NSVGYVKGRM PRMVDDLLDV VPRFYTRQEL EDLLDD
//