ID   H2EZN9_9CORV            Unreviewed;        39 AA.
AC   H2EZN9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Lactate dehydrogenase B {ECO:0000313|EMBL:AEX66034.1};
DE   Flags: Fragment;
GN   Name=LADHB {ECO:0000313|EMBL:AEX66034.1};
OS   Vanga curvirostris.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Vangidae; Vanga.
OX   NCBI_TaxID=125301 {ECO:0000313|EMBL:AEX66034.1};
RN   [1] {ECO:0000313|EMBL:AEX66034.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22217720; DOI=10.1098/rspb.2011.2380;
RA   Reddy S., Driskell A., Rabosky D.L., Hackett S.J., Schulenberg T.S.;
RT   "Diversification and the adaptive radiation of the vangas of Madagascar.";
RL   Proc. R. Soc. B 279:2062-2071(2012).
CC   -!- FUNCTION: Interconverts simultaneously and stereospecifically pyruvate
CC       and lactate with concomitant interconversion of NADH and NAD(+).
CC       {ECO:0000256|ARBA:ARBA00033729}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate;
CC         Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;
CC         Evidence={ECO:0000256|ARBA:ARBA00033677};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23445;
CC         Evidence={ECO:0000256|ARBA:ARBA00033677};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23446;
CC         Evidence={ECO:0000256|ARBA:ARBA00033677};
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DR   EMBL; JQ239369; AEX66034.1; -; Genomic_DNA.
DR   AlphaFoldDB; H2EZN9; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF2; L-LACTATE DEHYDROGENASE B CHAIN; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          1..39
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEX66034.1"
FT   NON_TER         39
FT                   /evidence="ECO:0000313|EMBL:AEX66034.1"
SQ   SEQUENCE   39 AA;  4232 MW;  14C759B7EAF50752 CRC64;
     LQHGSLFLHT HKIVADKDYA VTANSKIVVV TAGVRQQEG
//