ID H2J4F5_MARPK Unreviewed; 472 AA.
AC H2J4F5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|RuleBase:RU004355};
DE EC=3.1.11.6 {ECO:0000256|RuleBase:RU004355};
GN OrderedLocusNames=Marpi_0363 {ECO:0000313|EMBL:AEX84810.1};
OS Marinitoga piezophila (strain DSM 14283 / JCM 11233 / KA3).
OC Bacteria; Thermotogota; Thermotogae; Petrotogales; Petrotogaceae;
OC Marinitoga.
OX NCBI_TaxID=443254 {ECO:0000313|EMBL:AEX84810.1, ECO:0000313|Proteomes:UP000007161};
RN [1] {ECO:0000313|EMBL:AEX84810.1, ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RX PubMed=23045491; DOI=10.1128/JB.01430-12;
RA Lucas S., Han J., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N.C., Ivanova N., Pagani I., Vannier P.,
RA Oger P., Bartlett D.H., Noll K.M., Woyke T., Jebbar M.;
RT "Complete Genome Sequence of the Thermophilic, Piezophilic, Heterotrophic
RT Bacterium Marinitoga piezophila KA3.";
RL J. Bacteriol. 194:5974-5975(2012).
RN [2] {ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Jebbar M.,
RA Vannier P., Oger P., Cario A., Bartlett D., Noll K.M., Woyke T.;
RT "Complete sequence of chromosome of Marinitoga piezophila KA3.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000256|RuleBase:RU004355};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004355}.
CC -!- SIMILARITY: Belongs to the XseA family.
CC {ECO:0000256|RuleBase:RU004355}.
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DR EMBL; CP003257; AEX84810.1; -; Genomic_DNA.
DR RefSeq; WP_014295882.1; NC_016751.1.
DR AlphaFoldDB; H2J4F5; -.
DR STRING; 443254.Marpi_0363; -.
DR KEGG; mpz:Marpi_0363; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_4_2_0; -.
DR OrthoDB; 9802795at2; -.
DR Proteomes; UP000007161; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-EC.
DR GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR NCBIfam; TIGR00237; xseA; 1.
DR PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|RuleBase:RU004355, ECO:0000313|EMBL:AEX84810.1};
KW Hydrolase {ECO:0000256|RuleBase:RU004355};
KW Nuclease {ECO:0000256|RuleBase:RU004355};
KW Reference proteome {ECO:0000313|Proteomes:UP000007161}.
FT DOMAIN 141..452
FT /note="Exonuclease VII large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02601"
SQ SEQUENCE 472 AA; 53943 MW; 87A1ED98263E9478 CRC64;
MKQFKDLISL IDWVSSELKT TELFSDSITF IGDISRAKLS TSKDLFIEVS QRLGTGKTYK
INIFLSRYYV KTLLENLELK DVSDLENKSW KIVGRLSFWP SSSNIAITLK SLSPVGESKL
EKRRRVILNK LKLEGLLRTA NNTLEMLPPI KKIAVISSET AAGYGDFVKN INKTKYPPLI
HLYPSPMQGV EVPVGIISAL KNILKSKIDY DLVVIIRGGG SQADLMYFDD FNLAQHIAYF
SNNKIPIVTG IGHEQDTTIL DFVSYIRFST PTEVARAINN QIEFFHQTLH EKFQNIIYEI
NSNFTTTEIK LKNLSENLSI YFNNITKNQE NYLKEMSNKI NNINKFFEMN EKALNSRLDF
INLISNHINN KLINFSSVIN NEKNLIQKNM ENKLNMSFQR IDELYIKITQ NSPFSAFLSN
GAIVIQNGEI VNTIKNLKID PVEIKFKDGE AKGKIESINY YNNIGGEKND NR
//
