ID H2KVB9_CLOSI Unreviewed; 740 AA.
AC H2KVB9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Protection of telomeres protein 1 ssDNA-binding domain-containing protein {ECO:0000259|Pfam:PF16686};
GN ORFNames=CLF_111831 {ECO:0000313|EMBL:GAA30396.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA30396.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA30396.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA30396.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the telombin family.
CC {ECO:0000256|ARBA:ARBA00008442}.
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DR EMBL; DF144447; GAA30396.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KVB9; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR028389; POT1.
DR InterPro; IPR032042; POT1PC.
DR PANTHER; PTHR14513; PROTECTION OF TELOMERES 1; 1.
DR PANTHER; PTHR14513:SF0; PROTECTION OF TELOMERES PROTEIN 1; 1.
DR Pfam; PF16686; POT1PC; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 99..245
FT /note="Protection of telomeres protein 1 ssDNA-binding"
FT /evidence="ECO:0000259|Pfam:PF16686"
SQ SEQUENCE 740 AA; 82469 MW; C469CA7658541726 CRC64;
MHRLIVKEFR GECQGCGYGT VGFSATVFSG STSDPLVPRP SKANCSFGDE ELRRVRELRE
WFNSPGCPVE REPIVDHNDP SQSLQRTKPA SLVKRLWCLQ PEEFTSTEGQ VVAIYRYPQR
DRCCLLYVWD GAPPFSSSTT LPSFMRPPKG HMVRLSQNAH HDPKLCAITA HESSCPSVDD
WSVPVFIYDE HASAPVLQNL KPGDIVRIHN LHVTLCRPLE CDKDGCLRLL VHGGGHRFGR
GLQLLRPGFS EGLSYTSTQN REARPDDSFS VTSLYGLSSN LQDGIKSRPF YLELKVERPA
KALTVSELCA IPATYQQLET EKFGLSSTSL FNTNSSTSST PPHVHWFPVT SDGANRRNRT
VVMARLMARV LDIFPRTVDD LKNVSLLICS QCHSAIRVSC FDVGELPCSC HLSRTSAADG
SEIFMLAPFV FLKVEDPTGQ LIVCASFASA IALLMQSNSS SVQDRGWKQI TNELLRPKTS
DGSLLASLRA VHQLSFLLNQ PVNLVLELSW LAVTSYTFPD QNQTSSGLWE ILEFLNGDSV
LQVKQIYTEK HCTSTSSILG IISRNFRHMR VRFFSSGNPG ASSGVVVACF LDGVNKLLTD
GEIPVKDRLC TITNHWFSLR SGSHNFLFDD LPLAYVVVCR TVDAGNQRKE IHTLIRTKLR
KHNTVLLDYP GKRLGPFLLL NRAKTDTVVE LIIIVESPVE RLKLHAVYGL RELVEFYESL
ANDQRVWVAA SREAGSVRDG
//
