ID H2KZV6_CAEEL Unreviewed; 881 AA.
AC H2KZV6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Rho GTPase-activating protein 26 {ECO:0000313|EMBL:CCD69972.1};
GN ORFNames=CELE_T04C9.1 {ECO:0000313|EMBL:CCD69972.1}, T04C9.1
GN {ECO:0000313|EMBL:CCD69972.1, ECO:0000313|WormBase:T04C9.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD69972.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD69972.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69972.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284603; CCD69972.1; -; Genomic_DNA.
DR RefSeq; NP_741163.2; NM_171143.7.
DR AlphaFoldDB; H2KZV6; -.
DR SMR; H2KZV6; -.
DR STRING; 6239.T04C9.1a.1; -.
DR EPD; H2KZV6; -.
DR PaxDb; 6239-T04C9-1a; -.
DR PeptideAtlas; H2KZV6; -.
DR EnsemblMetazoa; T04C9.1a.1; T04C9.1a.1; WBGene00020209.
DR GeneID; 175849; -.
DR KEGG; cel:CELE_T04C9.1; -.
DR AGR; WB:WBGene00020209; -.
DR WormBase; T04C9.1a; CE32714; WBGene00020209; -.
DR eggNOG; KOG1451; Eukaryota.
DR InParanoid; H2KZV6; -.
DR OMA; MRSPMVQ; -.
DR OrthoDB; 5395569at2759; -.
DR PhylomeDB; H2KZV6; -.
DR Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR Reactome; R-CEL-9013148; CDC42 GTPase cycle.
DR Reactome; R-CEL-9013149; RAC1 GTPase cycle.
DR Reactome; R-CEL-9013405; RHOD GTPase cycle.
DR Reactome; R-CEL-9013406; RHOQ GTPase cycle.
DR Reactome; R-CEL-9013409; RHOJ GTPase cycle.
DR Reactome; R-CEL-9013423; RAC3 GTPase cycle.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00020209; Expressed in larva and 4 other cell types or tissues.
DR ExpressionAtlas; H2KZV6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd07602; BAR_RhoGAP_OPHN1-like; 1.
DR CDD; cd11882; SH3_GRAF-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF1; RHO GTPASE-ACTIVATING PROTEIN GRAF; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Proteomics identification {ECO:0007829|EPD:H2KZV6,
KW ECO:0007829|PeptideAtlas:H2KZV6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 269..386
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 403..590
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 822..881
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 594..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 225..256
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 615..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 99050 MW; 1F11F70E437A96C6 CRC64;
MVLRALEFSD SISDSPWFRQ NLHDHEVALD DAFKNIKLIE NQCKELIACT KKLSTAQRAF
AKTLSEFKFE TVGTNQTDDE RFIATCLKEF GSLINQVEDE RMKLVGQAEE SYLEPIKKFR
TEAIGRTLKE EKNKYDKESS KFYQTLEKHL HLSTVRNNDF RAADAQLETQ QKNFFQASLQ
YVAEVQSVQE RMRFEFVETL GSYVYSWLSF FHVGSVIHQD FKPFLDNVQT KVQKTKENYN
ATNAEAEELK KKLLASHTKP GSEDRRPTPS IKQGYVYMQE KSKIPKTIGR DVLLGRWTKY
YCVYSRETRI FTMVSANSAT KTDMKSAVAQ TATFKFKSCS RRPMDSIDKR FCFDVCVEEK
NDVMTMQALS EKDLCEWIDA MDGAKQNSYT AGENPSCSTY KQTQLDDIGF EFVQQCIDIL
EESGIHEQGV YRNCGVTSKV QKMMMLGLDR RKASEKGGLN LRDDEWETKT ISSAVKTFLR
NLPEPLMTFE LHNVFINAAK MGDATMRIDH IHFYVHQLPA QHLRMLEIVV RHLKRVADLS
NENLMTVSNL GVCFGPTLLR PKEETVAAIM DIKFCNVVVE VLISNYDKIF KSKPKSSFGS
AVPPKPDHHT SYDNGRPLAT RSFGTSTPSP ITSRSRSPKT PGVGSKIVRS TQVVSSSYSR
GMQKRDAMYP SEIARHGIGF DVGELGDFQI ENNRSPLTSP TGIAPLASGS IEEIDEVAKK
ERNSSDSLNS LGSFGSVGDE STATVVAAPD GFGKSIVKPK YSVSYASTYN RIPADSSKLT
SSISCTTVDS TGVVETSFTS LTRQNYLRGT LDSSSMGTTY KYLSRRVKTL YACTPDHHSE
LSFEPGQIIT NVYESNEDGW LVGTLNGKTG LIPSNYVEPL P
//
