ID H2L2V8_ORYLA Unreviewed; 1164 AA.
AC H2L2V8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=MCF.2 cell line derived transforming sequence-like 2 {ECO:0008006|Google:ProtNLM};
GN Name=mcf2l2 {ECO:0000313|Ensembl:ENSORLP00000000060.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000060.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000060.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000060.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000060.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000060.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2L2V8; -.
DR Ensembl; ENSORLT00000000060.2; ENSORLP00000000060.2; ENSORLG00000000049.2.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00940000161734; -.
DR HOGENOM; CLU_007130_1_0_1; -.
DR TreeFam; TF318080; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000000049; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF211; GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 94..192
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 623..802
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 814..936
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 522..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 131770 MW; 76367DC610A11C62 CRC64;
MLCWLKEDEM SVQELLQRVQ CVITHVDEIM QQDIRPLLAV DIIEQLHLQF ALLSGGRGKD
GAPIIIFPEY SGFSEVPEED FLNVVTYLTS IPSLDAASIG FIIIMDRRKD KWSSVRGCLS
RIAGAFPGHL QLVLVLRPSR FFHRTVTDIG IKMHKDDFKM KIVMLNSLSD LHGYVDKSQL
TRELGGSLDY NHSQWMHHRT AIENFAMTVK STAQMLQRFG NELAETDLPQ DVQSTKDLLA
AHTDRHNHLK DELKLALRQG STLSGCIKEQ AAKSENHELN PDETENQTTV ERLMAQLDET
DNAFEQFWSK HHLKLEQCLQ LRHFEKDFRE VKVTLDGLMN SVNTLADTAD CAARVELLLK
DLKALEDKAR PSLEKAQLQA LHGDQLIQSS HYAVDSIRPK CVELRRVCDD FSNEVQKKHD
VLSKSLQIHR GIDKVNQWCD SGIYLLASQA VDKCQSQEGA ESALTDIENF LESAEKNQLT
ELKNLHNQFE MVLSEDLKGS VQMVLKRLED VQEMFEKRHV SLKRLSAKQT RPIQPVAPRP
DSSPKRPSLR NPPRATGSPQ SFARRAADNS HSGRQAAEVD PNKKKNTRKT KAGIKIEVMH
EESQGGSAHV VAPAESEESL SSRRRHIMTE LIETERIYVE ELQSILEGYY VELNNSEFSH
LIPPSLENKR DVLFGNLPEI YDFHNKTFLM ELENCVEKPE LVGSCFLNRK EELQVYEKYC
QNKPRSEVLW RQCGDSLFFQ ECQKKLDHKL SLDAYLLKPV QRITKYQLML KEMLKCSKDE
GMVELEEALA TVIDIIKSVN DSMHQIAITG FDGNLSELGK LLMQGSFNVW TDHKKVHSKV
KDLARFKPMQ RHLFLYNKML LFCKKREDAT EGYEKTPSYS FKHSLKMSAV GITENVKGDS
KKFEVWYNGR EEVYIIQAPS MEVKNIWVSE IRKVLTGQLE ACREASQLNI YSAPIRNVRK
MALRQSDSSS PELGFRRTNP GPNTRQKKAD TSAGRLAHSA GNARKHFSLQ ALSNRRSLPA
EPAAKEAEVP RRFSLTSSLA SSSSISARRT KDTLNGAIAA ARKRQSMTGS TGSGAGGTPS
VPRSTSQPGC VQQRLLSMDT EDFETIPSSA EESSNSSEED SISKNRNSSQ YRVQLTYTSC
EARDLSLGGS DLVPFREETE NGNW
//
