ID H2L431_ORYLA Unreviewed; 918 AA.
AC H2L431;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000512.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000512.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000512.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000512.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000512.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2L431; -.
DR Ensembl; ENSORLT00000000512.2; ENSORLP00000000512.2; ENSORLG00000022109.1.
DR eggNOG; ENOG502SBIG; Eukaryota.
DR GeneTree; ENSGT01070000253760; -.
DR InParanoid; H2L431; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000022109; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 161..295
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 29..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 103405 MW; 5B530EEEBCDF216E CRC64;
MIRVSLELPT DCFDCCSLTF LLSVHREKKR SGPQSAERAR AGESEPDHLL MDSSGNMWNT
HEGAFFSALS ADVGLQEMFG EHQISLRSRS EHVAEGTEGR ETLLNRVYTE LYITEGLRPE
AHTQHEVMQL ETTTKTNQLH DTAIKNPDIF KVLPDQHRSI RVVLTSGVAG AGKSFSVQKF
TLDWAEGLEN QDISAVVPLF FREMNLIRDE QHSLLTLIQL FHPTLQKIPA EQLSVCKLLF
IFDGLDESRL SLDFNNSPLV SDVTHKSSVN VLLTNLIQGR LLPSALVWIT SRPAAANQIP
PSCVDRLTEV RGFNDAQKEE YFRRRFPDGE LSSRIISHIK GSMSLYIMCE VPVFCRITAV
VLENLLTTEQ RGELPTTLTD MYSHFLMVQT KRKKNKEVLL KLGRLAFEHL EKGNIMFYQE
DLQQCGLDVT EASVYSGVCT EIFRRECGIF QKPIYSFVHL SVQEFLAAVY MFHCYSNRKV
KSKTGHLDLL VRFLHGLSVE SNQRLLGGLL GQTEKNPETI QRAINNLKEI NNGGVSPDRS
INIYHCLMEM KDLSVHQEIQ EFLKSENKSE KKLSEIHCSA LAYTLLMAEE VLDELDLNQY
KISSAEGMRR LIPAVRNCRK FRFPQRCGLS ETHCEIVASA LKSNPSHLTE LDLSNDSLED
SSMKVLCPGL ESPKCRLQTL RLVNCSLSEN SCETLGSALK KNPFNLTKLD LSVNNKMQDS
GVLHLCGFME SPDCRLQTLS LSEISCKSLV SALKKNPSNL TELDLSKNNL QDSGVLHLCG
FMESPDCRLQ TLRSDSMFQL CSDQYDDKVV LTHSEQKCPD SFLPAAVCSL QRSAEQLLLF
FLCAALVSAL KSNPSHLTEL DLRLNDLQSS DVQQLQDLVE SPNSKLQTLR SVEGWSRSSC
FQTFGPKVSL RTKLQSFL
//
