ID H2L4A7_ORYLA Unreviewed; 425 AA.
AC H2L4A7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Keratin, type 1, gene c5 {ECO:0000313|Ensembl:ENSORLP00000000595.2};
GN Name=krt1-c5 {ECO:0000313|Ensembl:ENSORLP00000000595.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000595.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000595.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000595.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000595.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000595.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_004072100.1; XM_004072052.2.
DR AlphaFoldDB; H2L4A7; -.
DR STRING; 8090.ENSORLP00000000595; -.
DR Ensembl; ENSORLT00000000595.2; ENSORLP00000000595.2; ENSORLG00000000488.2.
DR GeneTree; ENSGT00950000182969; -.
DR HOGENOM; CLU_012560_8_2_1; -.
DR InParanoid; H2L4A7; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000000488; Expressed in bone element and 11 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF354; KERATIN, TYPE I CYTOSKELETAL 18; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 69..380
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 18..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..107
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 192..223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 264..379
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 425 AA; 48311 MW; C0FED4F7C75FDCB5 CRC64;
MASTLSVRSY SLRQPGLSSV SIRDGGRGLR AKTPMSQLSS PLSRSLSVGN GLNVLGSPTF
SRNGLGASEK ETMQVLNDRL ANYLHKVRSL ERSNAELEMK INQLMLERTP KGHDIESMMA
QAHAIGQEVR KKSLENARIM LEIDNARLAA DDFRVKWEAE AALCQSVERD CQALKRAKSD
HDQIVGTLRG DLDSLKEELY FLKKNHEEEM NSLKSHLANE QVKVEVDVTQ GPDLGAIMAE
LRVQYEGITR KNKEDAETWY LKKVDAVQSE VKENNEALRC AQTELSERRR FLQALEVELD
SVRRQVGVLE GNLGETGHKY TVEMDHLQTN LMQLEDELSQ LRLDMQRNKT DYEQLLRIKQ
NLEMEIATYR RLLEGEEMVK EKPPPPKKEP DVRTRKIVKV VTQTMINGKV VGESSEVEQI
EEDKN
//
