ID H2L656_ORYLA Unreviewed; 822 AA.
AC H2L656;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=RNA binding motif protein 5 {ECO:0008006|Google:ProtNLM};
GN Name=LOC101169440 {ECO:0000313|Ensembl:ENSORLP00000001300.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001300.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001300.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001300.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001300.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001300.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_011472954.1; XM_011474652.1.
DR RefSeq; XP_011472955.1; XM_011474653.1.
DR AlphaFoldDB; H2L656; -.
DR STRING; 8090.ENSORLP00000001300; -.
DR Ensembl; ENSORLT00000001301.2; ENSORLP00000001300.2; ENSORLG00000001053.2.
DR GeneID; 101169440; -.
DR KEGG; ola:101169440; -.
DR eggNOG; KOG0154; Eukaryota.
DR GeneTree; ENSGT00940000156617; -.
DR HOGENOM; CLU_010527_0_0_1; -.
DR InParanoid; H2L656; -.
DR OrthoDB; 298711at2759; -.
DR TreeFam; TF315789; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000001053; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12755; RRM2_RBM5; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034993; RBM5_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR001876; Znf_RanBP2.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF21; RNA-BINDING PROTEIN 5; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF17780; OCRE; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 86..166
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 169..198
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 219..303
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 750..796
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 681..715
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 90754 MW; 83C59774A2B7E1AD CRC64;
MGTDRGLSRG ERSGRYGSDG RGDDPEWSRQ KEGSSMDDRP RELCDEPREG DSPGRKRKRQ
SSDQSDDEYD GDFPEQDGKM EMEESNTIML RGLPPSVTEE DIGKALEELQ GPQPVDIRLM
KKRAGISRGF AFVEFYHLQD STRWMETNQK KLLIQGKSVA VQYSNRRQKF ENWLCNSCGL
YNFRKRVKCY RCGTCKTGES PGGNGLNIEA QQAGEIPGDT IILRNIAPTS TVEGILTILA
PFANLSTSNV RLIKDKQTGQ NRGFAFVQLS TPLEASQLLT ILQSLQPPLK LDGKTVGVDF
AKSARKDSVQ TDVIRANALS VASTAIAAAQ WSSSQLPQSS RASASLPEGH AEQTQRTANP
VWPHPPVPVA GDGLLGAAPA VKTIIPAAAG VIVPQTAHVY QPALQTHQLM LQLQASQQAA
GVCSASPVTP ASATVDTAVC AGPTVNTVAV PDPSAYQYDE SSGYYYNPHT GLYYDSSSQY
YYDCETQQYL YWDSETQTYA PAPSEPVSNA ESNANGPAGS STTAAKEPKE KKQKFKNKSA
QQIAKDMERW AKSLNKQKEN VRNNNQTFGS CREEDRKESL AADAAFFLFE RKVNKTGGFE
VSDLIGEHVQ IPELDASTKG DADPVRVVES DQEESGMERL EGEEEKLTDW KKLLCLLCRR
QFPTKEALLR HQQLSDLHKQ NLDIQKRSKL SETELEDLER KEAELKYRDR AAERREKYGV
TEPPAPKRKF YQASAPVVNY EQPTKDGLTS DNIGSKMLQA MGWQEGRGLG RHQQGITTPI
AASLRAKGTG LGSKGSSYEL SPSDTYKDAV RKAMFARFTE IE
//
