ID H2L902_ORYLA Unreviewed; 1301 AA.
AC H2L902;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Protein transport protein Sec31A {ECO:0000256|ARBA:ARBA00039468};
DE AltName: Full=SEC31-like protein 1 {ECO:0000256|ARBA:ARBA00043112};
DE AltName: Full=SEC31-related protein A {ECO:0000256|ARBA:ARBA00041470};
GN Name=sec31a {ECO:0000313|Ensembl:ENSORLP00000002335.4};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002335.4, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002335.4, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002335.4,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002335.4}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002335.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC31 family.
CC {ECO:0000256|ARBA:ARBA00009358}.
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DR STRING; 8090.ENSORLP00000002335; -.
DR Ensembl; ENSORLT00000002336.4; ENSORLP00000002335.4; ENSORLG00000001874.4.
DR eggNOG; KOG0307; Eukaryota.
DR GeneTree; ENSGT00390000003175; -.
DR HOGENOM; CLU_003033_1_0_1; -.
DR InParanoid; H2L902; -.
DR TreeFam; TF313842; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000001874; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 1.25.40.1030; -; 1.
DR Gene3D; 1.20.940.10; Functional domain of the splicing factor Prp18; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR040251; SEC31-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13923:SF23; PROTEIN TRANSPORT PROTEIN SEC31A; 1.
DR PANTHER; PTHR13923; SEC31-RELATED PROTEIN; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022892};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 118..154
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 256..298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 507..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..530
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..596
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..930
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1035
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1301 AA; 140108 MW; 78BF9ADAAF134702 CRC64;
MKLKEVNRTA IQSWSPAQHH PIYLATGTSA QQLDASFSTN ASLEFFELDL ADPTLDMKSC
GSFSSAHRYY KLVWGPFGMD SQNHPAGVLI AGGENGNVIL YDPARIMAGK SDVVITESDR
HSGPVRALDV NPFQANLVAS GGNESEIFIW DMNNFGSPMT PGPKTQPLED ISCVAWNRQV
QHILASASPS GRASVWDLRK NDLIIKVSDH SNRMHCSSLA WNPEVATQLV LASEDDRMPV
IQMWDLRFAT SPLKILEHHT RGILAISWSL ADPELLLSCG KDSRILCWNP NTAEVLYELP
TSSQWCFDIQ WCPRNPAVLS AAGCDGHIDI FSIMGGSNQA QSQRHADQIS NSFGNMDPFG
TGQTLPPLQL PQTSAPPASV IPLRKPPKWI CRPVGASFAF GGKLVSLDNA KPQQQQPSSH
LVHISQVVTE TALLDRSEQL QATLSSRNFV GFCQEKIDAA ENEFEKTLWS FLKVNFESDV
RSKYLELLGY NREELASKIS AALAEKPADL PQPDPSVPAP LQPPADLPPA DAPEAAFDWI
AAANSQPAVT LSPTPESEEP EEPAEDGQEA NLDQVLQEDE EAEEKEEEEE IPLNEDVAAP
AEEISPAETP AAVPAPTPAG VALSISQDVD GLITQALLTG DFEAAVELCL HDNRMADSII
LAIAGGAELL ETTQRKYFTK TRSRITKLIS AVVTKDWHDI LRTCDLQNWK EALAAVMTYA
RPEEFSSLCD LLGGRLEAAE DAQLKSQACL CYICAGNVEK LVSCGTRAQA GHSPLSLQDL
VEKVVVLRQA VEQTQRSGPA AIGVLLAEKM SLYANLLAAQ GSLATAITYL PDDTNQVSVQ
QLRNRLSRAL GHQVAAPPTH PQGVPSHHPQ PGSAPFVPAQ QPAAPPAQQH YRQPVRAAST
VTSWSNQTPT ALPNVPPLPH PHPVGSASNP QAEPPAPGYR MLTPASAAPP PASSAPAYAF
SHQYQPFPQV NRYPSQAGGQ PAYPPQYSSA APPQTPPTDP SSPPPHPPGF LPQYTQPVPP
QPAPLRYPGQ PPSSHPDFFP SSSSASSSSS SSFSALPSFG ESFQHGGPGS PVSYLPPPLT
GVSGPQNGWN DPPSLTHASK KKQLPENYTP PAPITAPIMA PLGTDPMAQQ IPPAAPQGPQ
VPFSGMHQQQ LTPPSVNPAM PNTSMEGAPG APTGDMIQPL QSIPAEKILK KPIPEEHLIL
KTTFESLIQK CLAVAADPQT KRKLDEASKR LEALYDKLRE QTLSPPIITG LHNITRSIEA
RSYTESLNIH THIVSHSNFS ETSAFMPVLK VVLTQANKLG V
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