ID H2L9J9_ORYLA Unreviewed; 780 AA.
AC H2L9J9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN Name=CUL5 {ECO:0000313|Ensembl:ENSORLP00000002543.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002543.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002543.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002543.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002543.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002543.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR RefSeq; XP_004075304.1; XM_004075256.2.
DR AlphaFoldDB; H2L9J9; -.
DR STRING; 8090.ENSORLP00000002543; -.
DR Ensembl; ENSORLT00000002544.2; ENSORLP00000002543.1; ENSORLG00000002038.2.
DR GeneID; 101165410; -.
DR KEGG; ola:101165410; -.
DR eggNOG; KOG2285; Eukaryota.
DR GeneTree; ENSGT00940000156648; -.
DR HOGENOM; CLU_004747_5_0_1; -.
DR InParanoid; H2L9J9; -.
DR OMA; FNILTCR; -.
DR OrthoDB; 5474206at2759; -.
DR TreeFam; TF105874; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000002038; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0031466; C:Cul5-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 403..638
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 780 AA; 91028 MW; 7F210BB5C991C8F3 CRC64;
MATSNLLKNK GSLQFEDKWD LMRPIVLKLL RQEAVTKQQW FDLFSDVHAV CLWDDKGPAK
IHQALKEDIL DFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG
KQGSNKKTNM EDSIVRKLML DTWNESIFSN IKSRLQDSAM KLVHAERLGE AFDSQLVIGV
RESYVNLCSN PEDKLQIYRD NFEKAYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLRE
EEKRALRYLE TRRECNSVQA LMECCVNALV TSFKETILAE CPGMIKRNET DRLHLMFSLM
DKVPNGTEPM LKDLEEHIVN AGLADMVAAA ETITTDSEKY VEQLLTLFNR FSKLVKEAFQ
DDPRFLTARD KAYKAVVNDA TIFKLELPMK QKGVGMKTQP ESKCPELLAN YCDMLLRKTP
LSKKLTSEEI ELKLKEVLLV LKYVQNKDVF MRYHKAHLTR RLILDISADS EIEENMVEWL
REVGMPADYV NKLARMFQDI KVSEDLNQVF KEMHKHNKLA LPADSVNIKI LNAGAWSRSS
EKVFVSLPTE LEDLIPEVED FYKRNHSGRK LHWHHLMSNG IITFKNEVGQ YDLEVTTFQL
AVLFAWNQRP REKISFENLK LATELPDAEL RRTLWSLVAF PKLKRQVLSY DPPVSSPKDF
TDGTLFYVNQ EFSLIKNSKV QKRGKINLIG RLQLTTERMR EEENEGIVQL RILRTQEAII
QIMKMRKRIS NAQLQTELVE ILKNMFLPQK KMIKEQIEWL IEHKYIKRDE ADINTFIYMA
//
