ID H2L9Y3_ORYLA Unreviewed; 290 AA.
AC H2L9Y3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Dimethylarginine dimethylaminohydrolase 2 {ECO:0000313|Ensembl:ENSORLP00000002683.2};
GN Name=ddah2 {ECO:0000313|Ensembl:ENSORLP00000002683.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002683.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002683.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002683.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002683.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002683.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DDAH family.
CC {ECO:0000256|ARBA:ARBA00008532}.
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DR RefSeq; XP_004073823.1; XM_004073775.2.
DR RefSeq; XP_011479034.1; XM_011480732.1.
DR STRING; 8090.ENSORLP00000040899; -.
DR Ensembl; ENSORLT00000002684.2; ENSORLP00000002683.2; ENSORLG00000002161.2.
DR Ensembl; ENSORLT00000034550.1; ENSORLP00000040899.1; ENSORLG00000002161.2.
DR GeneID; 101158865; -.
DR KEGG; ola:101158865; -.
DR CTD; 23564; -.
DR eggNOG; ENOG502QW4J; Eukaryota.
DR GeneTree; ENSGT00940000160769; -.
DR HOGENOM; CLU_067923_0_0_1; -.
DR OrthoDB; 315054at2759; -.
DR TreeFam; TF314737; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000002161; Expressed in blastula and 13 other cell types or tissues.
DR GO; GO:0016597; F:amino acid binding; IBA:GO_Central.
DR GO; GO:0016403; F:dimethylargininase activity; IBA:GO_Central.
DR GO; GO:0006525; P:arginine metabolic process; IBA:GO_Central.
DR GO; GO:0000052; P:citrulline metabolic process; IBA:GO_Central.
DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IBA:GO_Central.
DR InterPro; IPR033199; DDAH-like.
DR PANTHER; PTHR12737; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE; 1.
DR PANTHER; PTHR12737:SF16; N(G),N(G)-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2; 1.
DR SUPFAM; SSF55909; Pentein; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
SQ SEQUENCE 290 AA; 31305 MW; 7ED47A230AC9F3CE CRC64;
MANVCPYGRF THAVVRGIPE SFGKTAADGH ENGAVSVDLA KAQRQFGCLT GALRQKVGLQ
LIEIPPDAEL PESWRIEDVA VIQGDTALIA RPFQQQRRSE VKAVRRVMSE LNLTVVEMGA
EQGGSAGATL EGSDVLFTGR EFFVGISSHT NHGGAEVLAD TFRDFAVSTV PVCGGSRLKN
ICSMGGPDTI VFSSTEGAKK TLRVMEQLTD HRYEVLSVPE ESAANCIYVK GPSKKDFLLH
RPVEECPDSV SAFQKLPDYS LLPTACSEAS KLGASLSSLC LLINRKHTYF
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