ID H2LAZ4_ORYLA Unreviewed; 638 AA.
AC H2LAZ4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Nuclear RNA export factor 1a {ECO:0000313|Ensembl:ENSORLP00000003061.2};
GN Name=nxf1a {ECO:0000313|Ensembl:ENSORLP00000003061.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003061.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003061.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003061.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003061.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003061.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the NXF family. {ECO:0000256|ARBA:ARBA00009285}.
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DR AlphaFoldDB; H2LAZ4; -.
DR Ensembl; ENSORLT00000003062.2; ENSORLP00000003061.2; ENSORLG00000002462.2.
DR GeneTree; ENSGT00390000007539; -.
DR HOGENOM; CLU_011280_2_0_1; -.
DR Proteomes; UP000001038; Chromosome 10.
DR Bgee; ENSORLG00000002462; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR CDD; cd14342; UBA_TAP-C; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR002075; NTF2_dom.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR030217; NXF_fam.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR005637; TAP_C_dom.
DR InterPro; IPR015245; Tap_RNA-bd.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR10662; NUCLEAR RNA EXPORT FACTOR; 1.
DR PANTHER; PTHR10662:SF22; NUCLEAR RNA EXPORT FACTOR 1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF02136; NTF2; 1.
DR Pfam; PF09162; Tap-RNA_bind; 1.
DR Pfam; PF03943; TAP_C; 1.
DR SMART; SM00804; TAP_C; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
DR PROSITE; PS51281; TAP_C; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 403..555
FT /note="NTF2"
FT /evidence="ECO:0000259|PROSITE:PS50177"
FT DOMAIN 584..638
FT /note="TAP-C"
FT /evidence="ECO:0000259|PROSITE:PS51281"
FT REGION 22..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71926 MW; B5AB282C5382B9EA CRC64;
MFRKRYSNLS VVTRVLNDEH DDRTAPFRNR KGRGGHKGRP FDRSRRDRQR GSHTGVFGGP
GPRSRLDDPD GDVTMNDSSQ DSSSQNRYTP YSRDGRKGDG RVDRSRRQGR GAGGGRGGGF
REGDRGGLTV KARSGWYKVT IPHGKKYDKK WLVPALQNIC SVPYTPVQFH VDHNRVHFYV
DDHNTANALL KCSHKITDPE GYKVIVHVNP SAPPSFLLSD LKPEHLEYLK QCMAKRFDGS
QQALDLNNIR TDPDLVSQNI EVILNRKTSM EAVIKIIEEN IPELTCLNLS NNRIHKLDEL
AELVSKVPNL KTLNLSHNEL KTDRELDKLK GLKLVELWLN RNPLCALFKD QAAYISAVRQ
RFPRLLKLDG QDLPPPIGFD VETPTAIPPC KGSCFGSDEI KVIILRFLQQ YYSIYDSGNR
QPLLDAYHDG ASLSITTPYS TQNPSRSSLG EYYKDSRNLK RIKDTTMRFR LLKHTRLNVV
AFLNELPKTQ HDIASFVIDV NTCTNTLLSF TIGGVFKEVV VDGKSRESTM AFSRVFITVP
AGNSGLCIVN DQLFIRMATT EEIRRAFVAP APTPSSSPVP TLTAPQQEML TAFSQESGMN
LEWSQKCLQD NEWDFNRAAH IFTQLKAEGK IPDVAFIK
//
